负荷量双抗血小板联合低分子肝素治疗频发短暂性脑缺血发作的短期疗效

Short-term curative effect of loading dose of aspirin and clopidogrel and low molecular weight heparin on frequent transient ischemic attack

目的观察负荷量阿司匹林、氯吡格雷联合低分子肝素治疗短暂性脑缺血发作(aransient ischemic attack,TIA)的临床疗效及安全性。方法 96例TIA患者随机分为对照组和观察组。对照组使用单剂量阿司匹林和氯吡格雷,观察组用负荷量阿司匹林、氯吡格雷联合腹壁皮下注射低分子肝素,治疗1周时进行两组临床疗效评价。结果观察组的总有效率为91.67%,高于对照组的70.83%(P<0.01)。两组脑出血、消化道出血、牙龈出血、皮肤黏膜出血等不良反应差异无统计学意义(P>0.05)。结论负荷量阿司匹林、氯吡格雷联合低分子肝素治疗TIA疗效显著,安全可靠。

Objective To investigate the short-term curative effect and safety of a loading dose of aspirin and clopidogrel and low molecular weight heparin（LMWH） on frequent transient ischemic attack（TIA）.Methods Ninety-six patients with TIA were randomly divided into two groups：the control group treated with aspirin and clopidogrel and treatment group treated with a loading dose of aspirin,clopidogrel and LMWH.The clinical effects were analyzed in both groups after one week.Results The total effective rate was 91.67% in the treatment group,which was highter than that in the control group（70.83%）（P〈0.01,but there was no significant difference between the two groups in the incidence of intractable hemorrhage or gastrointestinal hemorrhage.There was also no significant difference in mucocutaneous hemorrhage or gingi-val hemorrhage between the two groups（P〈0.05）.Conclusions A loading dose of aspirin and clopidogrel and LMWH therapy is effective and safe for frequent TIA.