Slit2-Robo信号在眼底及全身血管生成的研究进展

Advanced studies on the role of Slit2-Robo signaling in angiogenesis of fundus oculi and some other organs

Slit是在果蝇中枢神经系统中发现的一类分泌型糖蛋白，Robo（Roundabout）蛋白为其受体。Slit-Robo信号在神经轴突导向、炎症反应、肿瘤转移以及血管生成等方面有着重要作用。Slit2是Slit蛋白家族的一个亚型，其在血管生成方面的作用受到广泛关注，且其对血管生成方面是促进还是抑制作用仍具争议。了解Slit2-Robo信号在眼底及其他血管生成的研究进展，可为探究其机制以及寻找治疗眼底新生血管的新靶点提供线索。

Axon guidance molecules, slit glycoprotein （Slit） and Roundabout receptors （Robo） were firstly identified in the central neural system of Drosophila melanogaster. The Slit-Robo signal plays a crucial role in axon guidance, inflammation, tumor metastasis and angiogenesis, of which the role of Slit2-Robo pathway in angiogenesis has drawn a greater attention and still remains conflicting. Herein, we provide a review on the role of Slit2-Robo pathway in ocular angiogenesis and vascularization of other organs and systems. We hope this review will be the basis of further study on the mechanism of Slit2-Robo signaling on angiogenesis and provide new target for the therapy on ocular vascular disease