消痞通降汤对功能性消化不良寒热错杂证患者胃敏感性的影响

The Influence of Xiaopi Tongjiang Decoction on Gastric Sensitivity of Patients with Functional Dyspepsia with Concurrence of Cold and Heat Syndromes

目的:探讨消痞通降汤对功能性消化不良(functional dyspepsia,FD)寒热错杂证患者胃敏感性的影响。方法:选取2013年9月至2016年9月北京市宣武中医医院脾胃科门诊收治的FD寒热错杂证患者90例,随机分为治疗组和对照组,每组45例。对照组脱落2例。对照组给予吗丁啉治疗,治疗组给予消痞通降汤治疗。结果:治疗组治疗后症状积分、中医证候积分优于对照组(P<0.05);两组西医总体疗效比较,治疗组有效率为91.1%,对照组有效率为69.8%,治疗组优于对照组,差异有统计学意义(P<0.05);两组中医证候疗效比较,治疗组有效率为93.3%,对照组有效率为67.4%,治疗组优于对照组,差异有统计学意义(P<0.05);治疗组治疗后胃肠激素水平优于对照组,差异有统计学意义(P<0.05);治疗组治疗后阈值饮水量、饱足饮水量、阈值近端胃容积水平优于对照组,差异有统计学意义(P<0.05);治疗组治疗后社会功能、身体疼痛和精神健康评分优于对照组,差异有统计学意义(P<0.05)。结论:消痞通降汤治疗功能性消化不良寒热错杂证疗效显著,改善患者胃敏感性,从而改善其临床症状。

Objective： To explore The Influence of Xiaopi Tongjiang Decoction(XPTJD） on gastric sensitivity of patients with functional dyspepsia with concurrence of cold and heat syndromes. Methods： Ninety patients with FD with concurrence of cold and heat syndromes who were treated in the outpatient of the spleen and stomach department of Beijing Xuan Wu TCM Hospital between September 2013 and September 2016 were chosen as the research subjects,and randomly divided into the treatment group and the control group,with 45 cases in each group,and 2 cases were lost in the control group. The ones in the control group received domperidone treatment,while the ones in the treatment group were treated with XPTJD. Results： After the treatment,the symptom score and TCM syndrome score in the treatment group were better than those in the control group(P〈0. 05）. In terms of the total curative effect of Western medicine of the two groups,the effective rate of the treatment group was 91. 1%,while that of the control group was 69. 8%; And the treatment group was better than the control group; And the difference between them had statistical significance(P〈0. 05）. In terms of the curative effect of TCM of the two groups,syndromes,the effective rate of the treatment group was 93. 3%,while that of the control group was 67. 4%; And the treatment group was better than the control group; And the difference between them had statistical significance(P〈0. 05）. The level of gastrointestinal hormone in the treatment group was better than that of the control group,and the difference between them had statistical significance(P〈0. 05）. The threshold of drinking water,the amount of full water and the threshold of the proximal stomach volume in the treatment group were better than those in the control group and the difference between them had statistical significance(P〈0. 05）.The social function,physical pain and mental health after the treatment in the treatment group were statistically significant. The score was better than that of the control group,the difference was statistically significant(P〈0. 05）. Conclusion： XPTJD has a remarkable clinical curative effect on functional dyspepsia with concurrence of cold and heat syndromes,can improve the patients＇ gastric sensitivity and the clinical syndromes.