摘要
用朝鲜数据的以前的研究已经更高报导了的 BackgroundAlthough 在女人死亡评价,在预后的这些性差别是否张贴圣片断举起,是不太清楚的心肌的梗塞(STEMI ) ,很长时间依赖者。这研究的目的是在病人与早、迟了的死亡检验性年龄相互作用, STEMI 在朝鲜全国性的 registry.MethodsThis 注册了未来的从 17,021 个 STEMI 病人根据性和年龄学习成层的结果。我们比较了在里面医院,早(30 天) 并且迟了(12 个月) 在性到之间的死亡在 multivariable models.ResultsIn 检验性年龄相互作用更年轻的女人(< 60 年) ,在里面医院[5.8% 对 2.5% , P < 0.001;unadjusted 机会比率(或) :2.41, 95% 信心间隔(CI ) :1.59-3.66 ] ,早(6.2% 对 2.6% , P < 0.001;unadjusted 或:2.4, 95% CI:2.12-2.72 ) 并且迟了的死亡(7.0% 对 3.1% , P > 0.001;unadjusted 或:2.33, 95% CI:2.08-2.61 ) 与男人相比是显著地更高的。然而在为耐心的特征的调整以后, Killip 班 3 ,症状到流血的汽球时间和专业,并且在里面医院流血全面早、迟了的死亡不再与在任何年龄 groups.ConclusionsAmong 的性有关有 STEMI 的一张朝鲜人口,在更年轻的女人的更高早、迟了的死亡可以被差的耐心的特征解释,更高的 Killip 班 3 ,更长的症状到汽球时间和流血的更经常的专业。基于性年龄差别,因此,更精确、好攻击的预防策略集中了于风险因素减小,教育和更集中的管理因为更年轻的女人应该被执行。
Background Although previous studies using Korean data have already reported higher rates of mortality in women, it is less clear whether these gender differences in prognosis post ST-segment elevation myocardial infarction (STEMI), are age dependent. The aim of this study is to examine the gender-age interaction with early and late mortality in patients with STEMI enrolled in the Korean nationwide regis-try. Methods This prospective study stratified outcomes according to gender and age from 17,021 STEMI patients. We compared in-hospital, early (30 days) and late (12 months) mortality between gender to examine the gender-age interaction in multivariable models. Results In younger women (〈 60 years), in-hospital [5.8% vs. 2.5%, P 〈 0.001; unadjusted odds ratios (OR): 2.41, 95% confidence inter-vals (CI): 1.59-3.66], early (6.2% vs. 2.6%, P 〈 0.001; unadjusted OR: 2.4, 95% CI: 2.12-2.72) and late mortality (7.0% vs. 3.1%, P 〉 0.001; unadjusted OR: 2.33, 95% CI: 2.08-2.61) were significantly higher compared with men. However, after adjustment for patient characteristics, Killip class ≥ 3, symptom to balloon time and major bleeding, and in-hospital bleeding, overall early and late mortality were no longer re-lated to gender in any age groups. Conclusions Among a Korean population with STEMI, higher early and late mortality in younger women may be explained by poor patient characteristics, higher Killip class ≥3, longer symptom to balloon time and more frequent major bleeding. Therefore, based on gender-age differences, more precise and aggressive preventive strategies focused on risk factor reduction, education and more intensive management for yotmger women should be performed.