大肠埃希菌生物膜形成与耐药机制的研究进展

Advances in research on Escherichia coli biofilm formation and antimicrobial resistance mechanisms

生物膜细菌与浮游菌相比有着其独特的生理学特性、毒力作用及耐药机制,对其耐药机制及治疗成为近年来的研究热点。大肠埃希菌(Escherichia coli)是医院感染的重要病原菌之一,也是生物膜感染的常见病原菌。形成生物膜的大肠埃希菌具有高度的耐药性并能逃避免疫系统的攻击,其感染易慢性化并难于控制。本文通过对大肠埃希菌生物膜形成与耐药机制研究特点进行阐述,为寻找有效的控制手段,指导抗生素合理使用提供理论依据。

Compared to their free living planktonic counterparts, the organisms within biofilms have their unique physiological characteristics. They are virulent and notorious for their resistance towards antibiotics, and their mechanisms of drug resistance and the prevention measures have become the focus of research in recent years. Escherichia coli are important pathogenic bacteria in hospital infections, and it is also the common pathogen of biofilm infections. Escherichia coli which forms the biofilm shows highly resistance and can escape the immune system attacks. The infections caused by Escherichia coli are easily to be chronic and difficult to control. The aim of this review focuses on the research progress of biofilms formation and its relevance with antibiotic resistance in Escherichia coll. It is of importance for finding effective management and guiding clinically proper drug application.