黄芪益肾颗粒治疗糖尿病肾病的疗效观察

Effect of Huangqi Yishen Granule(黄芪益肾颗粒) on Patients with Diabetic Nephropathy

目的:分析黄芪益肾颗粒对糖尿病肾病患者尿蛋白定量等相关指标的影响。方法:选择糖尿病肾病患者30例为研究对象,采用黄芪益肾颗粒治疗,观察患者尿蛋白定量、肌酐以及肾小球滤过率的变化。结果:治疗后24 h尿蛋白定量、血清肌酐均降低,内生肌酐清除率升高,差异均有统计学意义(P<0.05)。治疗后空腹血糖、餐后血糖、糖化血红蛋白均较治疗前降低,差异有统计学意义(P<0.05)。结论:黄芪益肾颗粒可降低糖尿病肾病患者24 h尿蛋白定量、血清肌酐、空腹血糖、餐后血糖及糖化血红蛋白,提高内生肌酐清除率。

Objective： To analyze the effect of Huangqi Yishen granule on urinary protein in patients with diabetic nephropathy. Methods： A total of 30 cases of diabetic nephropathy patients were recruited, and the effect of Huangqi Yishen granule on diabetic nephropathy was observed by detection of urinary protein quantification and filtration rate of creatinine and glomerular. Results： After the treatment, there were significant differences in the clinical parameters such as 24 h urine protein quantitation, serum creatinine and endogenous creatinine clearance rate（P〈0.05）. The fasting blood glucose, postprandial blood glucose and Hb A1 c were lower than before treatment（P 0.05）. Conclusion： Huangqi Yishen granule can reduce the 24 h urine protein quantitative,serum creatinine, fasting blood glucose, postprandial blood glucose and Hb A1 c, and increase endogenous creatinine clearance rate.