参芪二至汤加减对气阴两虚型IgA肾病患者尿IL-17、IL-6水平的影响

Effect of Shenqi Erzhi Decoction(参芪二至汤) on Urinary IL-17 and IL-6 in Patients with IgA Nephropathy of Qi-Yin Deficiency Syndrome

目的:观察参芪二至汤加减治疗气阴两虚型Ig A肾病(Ig AN)的临床疗效及对患者尿IL-17、IL-6水平的影响。方法:将60例气阴两虚型Ig AN患者随机分为治疗组(参芪二至汤加减+缬沙坦组)和对照组(缬沙坦组)各30例,观察治疗前后的24 h尿蛋白定量、血肌酐(SCr)、尿红细胞计数、尿IL-17、尿IL-6水平和中医证候积分变化。结果:对照组治疗2个月后尿蛋白定量、尿IL-17、IL-6定量、SCr和中医证候积分均下降,尿红细胞计数减少,差异均有统计学意义(P<0.05)。治疗组治疗1个月、2个月后尿蛋白定量、尿IL-17、IL-6定量、SCr和中医证候积分均下降,尿红细胞计数减少,差异均有统计学意义(P<0.05)。治疗后1个月、2个月两组比较,治疗组尿蛋白定量,尿红细胞计数、中医证候积分、尿IL-17、IL-6水平均低于对照组,差异均有统计学意义(P<0.05或P<0.01)。两组疗效比较,治疗组优于对照组,差异有统计学意义(P<0.01)。结论:参芪二至汤加减治疗气阴两虚证Ig A肾病疗效显著,可减少24 h尿蛋白定量、尿红细胞,降低SCr、尿IL-17、IL-6水平,从而更有效改善该型Ig AN患者临床症状。

Objective： To observe the clinical effect of Shenqi Erzhi Decoction on Ig A nephropath（Ig AN）with Qi-Yin Deficiency syndrome and its effect on the levels of urinary IL-17 and IL-6 in patients. Methods：A total of 60 cases of Ig AN patients with Qi-Yin Deficiency syndrome were randomly divided into treatment group（Shenqi Erzhi Decoction and valsartan group） and control group（valsartan group）, 30 cases for each. The change of 24 h urine protein, serum creatinine（SCr）, urine red blood cell count, level of urine IL-17, urine IL-6 and TCM syndrome score were observed before and after treatment. Results： The quantitation of urine protein,urine IL-17, urine IL-6, SCr, the socre of TCM syndrome, and the urinary red blood cell count of the control group were decreased after 2 month treatment, the difference is statistically significant（P〈0.05）. The quantitation of urine protein, urine IL-17, urine IL-6, SCr, the socre of TCM syndrome, and the urinary red blood cell count of the treatment group were decreased after 1 and 2 months treatment, the difference is statistically significant（P〈0.05）.The quantitation of urine protein, urine IL-17, urine IL-6, SCr, the socre of TCM syndrome, and the urinary red blood cell count of the control group was significant lower than the treatment group after 1 and2 months treatment, the difference is statistically significant（P〈0.05 or P〈0.01）. After treatment, the treatment group showed better efficacy than the control group（P〈0.05）. Conclusion： The curative effect of Shenqi Erzhi Decoction in the treatment of Ig A Nephropathy of Qi-Yin Deficiency syndrome is significant. It can effectively decrease the 24 h urine protein, urine red blood cells, SCr, urinary IL-17 and IL-6 levels, and thus more effective in improving the clinical symptoms of Ig AN patients.