针灸结合胃溃灵汤治疗青壮年胃溃疡的疗效及对溃疡愈合质量的影响

Effect of Acupuncture Assisted Weikuiling Decoction(胃溃灵汤) on Young Patients with Gastric Ulcer and the Influence on Ulcer Healing

目的:探讨针灸结合胃溃灵汤治疗青壮年胃溃疡的疗效及对溃疡愈合质量的影响。方法:选取我院86例青壮年胃溃疡患者,采用前瞻性随机研究分为联合组(西医基础治疗+针灸+胃溃灵汤)、对照组(西医基础治疗+胃溃灵汤)各43例,连续治疗8周。结果:治疗后,联合组的胃脘疼痛、烧心嘈杂、嗳气吞酸和口苦口干、烦躁易怒、大便秘结评分均低于对照组(P<0.05),联合组的血清胃泌素的水平低于对照组(P<0.05),联合组的血清VEGF、b EGF、NO、NOS高于对照组(P<0.05);治疗后联合组的A型+B型胃溃疡再生黏膜表面胃小凹率为88.37%、微规则血管形态86.05%均高于对照组的67.44%、67.44%(P<0.05);治疗后联合组的痊愈率为79.07%,对照组为58.14%,两组比较差异有统计学意义(P<0.05)。结论:针灸辅助胃溃灵汤治疗青壮年胃溃疡患者的临床效果肯定,溃疡愈合质量较好。

Objective： To investigate the clinical effect of acupuncture assisted Weikuiling decoction on young patients with gastric ulcer and the effect on ulcer healing. Methods： A total of 86 cases of young patients with gastric ulcer were selected, and a prospective randomized study was applied. Thepatients were divided into combined group（Western medicine ＋ acupuncture ＋ Weikuiling decoction） and control group（Western medicine＋ Weikuiling decoction）, 43 cases in each, 8 weeks of continuous treatment. Results： After treatment, the combination group showed lower epigastric pain, heartburn, belching Tunsuan and noisy mouth thirst, irritability and constipation scores than the control group（P〈0.05）; the combination group showed lower serum gastrin level than the control group（P〈0.05） as well as higher serum VEGF, b EGF, NO and NOS than the control group（P〈0.05）;after treatment, the mucosal surface of gastric pits regeneration rate was 88.37% in A type ＋B type gastric ulcer in the combination group and the rules of micro vascular morphology was 86.05%; the combination group showed higher mucosal surface of gastric pits regeneration rate and rules of micro vascular morphology than the control group（67.44%, 67.44%）（P〈0.05）; after treatment, the cure rate was 79.07% in combination group and58.14% in control group, and there was significant difference between the two groups（P〈0.05）. Conclusion：Acupuncture assisted Weikuiling decoction showed certainly clinical effect on young patients with gastric ulcer,with good quality of ulcer healing.