不同清肠液量及服用时间在结肠镜检查肠道准备中的效果研究

Effects of different amount of intestinal fluids and different administration time in the preparation of the intestinal microscopy

目的 探讨硫酸镁与复方聚乙二醇电解质散两种常用清肠剂的最佳配制方法,为临床结肠镜检查、治疗提供肠道准备依据.方法 选择2016年3月—2017年3月门诊及住院做结肠镜检的患者480例,按剂量及不同服用时间分别将硫酸镁与复方聚乙二醇电解质散清肠剂分为4个组,每组60例,比较各组肠道清洁效果和不良反应发生率的差异.结果 1 h内完成口服25%硫酸镁100ml＋温开水2000ml组患者全肠道清洁评定Ⅰ级53例,优于其他3组,组间比较（H=105.6541,P〈0.01）,等级间比较（H=124.2599,P〈0.01）.0.5 h内完成口服复方聚乙二醇电解肠质散2盒＋温开水1500 ml组患者全肠道清洁评定Ⅰ级51例,优于其他3组,组间比较（H=79.2803,P〈0.01）,等级间比较（H=145.5042, P〈0.01）.各组不良反应发生率差异无统计学意义（H值分别为47.25、19.50;P〉0.05）.结论 服用硫酸镁清肠剂进行结肠镜肠道准备时,25%硫酸镁100ml＋温开水2000 ml在1 h内服完的配制方法肠道清洁效果最好;服用复方聚乙二醇电解质散清肠剂时,复方聚乙二醇电解质散2包配制温开水1500 ml在1 h内服完的配制方法肠道清洁效果最好,适宜推广应用.

Objective To explore the optimized ratio of magnesium sulfate and compound polyethylene glycol electric dissolution of two common colon cleansing agent in the preparation of intestinal microscopy, so as to provide references for bowel preparation in clinical colonoscopy treatment. Methods A total of 480 cases of outpatients and inpatients for colonoscopy from March 2016 to March 2017 were selected. All the patients who took magnesium sulfate and compound polyethylene glycol electric dissolution were respectively assigned into four groups according to the dosage and different time of administration, with 60 cases in each group. The effects of bowel preparation and the incidence of adverse effects were compared. Results In the magnesium sulfate groups, there were 53 cases of ClassⅠthe score of bowel cleaning in the group of taking 25% magnesium sulfate 100 ml and water 2 000 ml orally in 1 hour, which was better than the other 3 groups. Hintergroup was 105.654 1 （P〈0.01）, and Hinterclass was 124.259 9 （P〈0.01）, and the differences was statistically significant. In the compound polyethylene glycol electric dissolution groups, there were 51 cases of ClassⅠthe score of bowel cleaning in the group of taking 2 boxes of compound polyethylene glycol electric dissolution with water 1 500 ml in 0.5 hour, which was better than the other 3 groups. Hintergrop was 79.280 3, and Hinterclass was 145.504 2, and the difference was statistically significant （P〈0.01）. There was no statistical significance in the differences of the incidence of adverse effects （H=47.25, 19.50;P〉0.05）. Conclusions When using magnesium sulfate in the colonoscopy bowel preparation, taking 25% magnesium sulfate 100 ml and warm water 2 000 ml in 1 hour by oral could get the best colon cleaning effects. When using compound polyethylene glycol electric dissolution, the best cleaning effect ratio is 2 boxes of compound polyethylene glycol electric dissolution with water 1 500 ml in 1 hour, which is suitable for popularization and application.