甲泼尼龙琥珀酸钠不同给药途径治疗突发性耳聋的疗效观察

Clinical Observation of Different Administration Routes of Methylprednisolone Sodium Succinate in the Treatment of Sudden Deafness

目的比较甲泼尼龙琥珀酸钠耳后注射和静脉滴注给药治疗突发性耳聋的临床效果。方法选取2016年1月-2017年6月就诊于抚顺市第二医院耳鼻喉科的81例突发性耳聋患者，两组均在常规治疗基础上给予甲泼尼龙琥珀酸钠，根据甲泼尼龙琥珀酸钠给药途径的不同，分为对照组（静脉滴注）41例和观察组（耳后注射）40例。观察两组疗效。结果总有效率对照组56．1％、观察组82．5％，差异有统计学意义（χ^2=6．61，P〈0．05）。不良反应发生率对照组24．4％、观察组2．5％，差异有统计学意义（χ^2=4．30，P〈0．05）。结论耳后骨膜下注射甲泼尼龙琥珀酸钠治疗突发性聋疗效显著，且安全性较高，值得推广使用。

Objective To compare the clinical effect of Methylprednisolone Sodium Succinate injection and intravenous infusion in the treatment of sudden deafness. Methods From January, 2016 to June, 2017, a total of 81 patients with sudden deafness were recruited in Department of ENT, Fushun Second Hospital, and all patients adopted methylprednisolone sodium succinate based on the routine treatment. According to the administration routes of methylprednisolone sodium succinate, all patients were divided into observation group （n=40, retroauricular injection） and control group （n=40, intravenous infusion）, and the clinical effects were compared. Results The total effective rate was 82.5% in observation group, and significantly higher than 56.1% in control group （χ^2=6.61 ,P〈0.05）. The adverse reaction rate was 2.5% in observation group, and was significantly lower than 24.4% in control group （χ^2=4.30, P〈0.05）. Conclusion The methylprednisolone sodium succinate postauricular subperiosteal injection has significant clinical effect in the treatment of sudden deafness, which is safe and worthy of clinical application.