摘要
目的:探讨Orexin-A对大鼠胃功能的影响。方法:通过大鼠迷走神经复合体微量注射Orexin-A后,观察大鼠胃运动、胃液和胃酸分泌的变化。结果:DVC微量注射Orexin-A后,大鼠胃收缩幅度以及收缩频率明显升高,且呈明显剂量依赖关系(P<0.05),SB334867可显著阻断Orexin-A对促胃运动效应(P<0.05)。DVC微量注射orexin-A后,大鼠胃液及胃酸分泌且呈剂量依赖性增加(P<0.05)。结论:迷走神经复合体微量注射Orexin-A能影响胃的运动以及胃内体液的分泌。
Objective： To explore the effect of microinjection of orexin-A into vagal complex（DVC） on the gastric function of rats. Methods： Orexin-A was microinjected into the DVC, the changes of gastric motility and gastric juice or gastric acid secretion were observed. Results： After the microinjection of orexin-A into DVC, the amplitude and frequency of gastric motility were signi覱cantly increased in a dose-dependent manner. SB334867 prevented Orexin-A-induced changes of gastric motility（P〈0.05）. After the microinjection of orexin-A into DVC, the secretion of gastric juice and gastric acid were significantly increased in a dose-dependent manner（P〈0.05）. Conclusion： Orexin-A could affect gastric motility and the secretion of gastric fluid.
作者
田彬
郝贺玲
杨丹丹
高胜利
徐珞
TIAN Bin;HAO He-ling;YANG Dan-dan;GAO Sheng-li;XU Luo(Dept. of Pathophysiology, Medical College of Qingdao University, Qingdao, Shandong, 266021, China;Department of surgery;Heze Career Academy, Heze, Shandong, 274000, Chin)
出处
《现代生物医学进展》
CAS
2018年第9期1633-1636,1610,共5页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(81470815
81270460
81500414)
山东省优秀中青年科学基金项目(BS2014YY009)
青岛市科技局项目(14-2-3-3-nsh)
