维吾尔族急危重症患者血清视黄醇结合蛋白与APACHEⅡ评分相关分析

Relationship between the scores of the serum retinol binding protein and APACHE Ⅱ score in critically ill Uygur patients

目的回顾性分析血清视黄醇结合蛋白(RBP)水平与APACHEⅡ评分在维吾尔族危重症患者中的动态变化,探讨RBP与APACHEⅡ评分的相关性以及对其预后的影响。方法选取医院综合ICU收住的符合研究条件的维吾尔族急危重症患者200例,按28 d生存率分为存活组和死亡组,于入院第1、3、5天收集患者血清RBP水平并进行APACHⅡ评分,并分析RBP水平、APACHⅡ评分相关性及病死率与RBP水平、APACHⅡ评分的相关性。结果第1天RBP水平和第1天APACHEⅡ评分呈中度负相关(P<0.01);第3天RBP水平和第3天APACHEⅡ评分呈轻度负相关(P<0.01);第5天RBP水平和第5天APACHEⅡ评分呈轻度负相关(P<0.01);病死率与入院第3天及入院第5天RBP水平均呈轻度负相关(P<0.01);病死率与入院第1天及入院第3天APACHEⅡ评分均呈中度相关(P<0.01),病死率与入院第5天APACHEⅡ评分呈高度相关(P<0.01)。结论通过测定血清RBP与维吾尔族急危重症患者APACHEⅡ评分的相关性,为维吾尔族危重患者早期病情评估提供依据。

Objective The dynamic changes of serum retinol-binding protein(RBP） and APACHE Ⅱ score in critically ill Uighur patients were retrospectively analyzed. The correlation between RBP and APACHE Ⅱ score and the effect on prognosis were analyzed. Methods 200 Uighur critically ill patients who met the study conditions were selected from comprehensive ICU hospitals and were divided into survival group and death group according to 28-day survival rate. Serum RBP levels were collected and scored on the first,third,and fifth days of hospital admission under APACH Ⅱ score evaluating standards. The correlation between RBP level and APACH Ⅱ score,and the correlation among mortality,RBP level and APACH Ⅱscore were analyzed. Results The level of RBP first days and first days APACHE Ⅱ score showed moderate negative correlation(P〈0. 01）. The third day RBP and APACHE Ⅱ score showed moderate negative correlation(P〈0. 01）. There was a mild negative correlation between RBP level and APACHE Ⅱ score on the 5 th day(P〈0. 01）. The mortality rate was slightly negatively correlated with the RBP level on the third day of hospital admission and the fifth day of hospital admission(P〈0. 01）. APACHE Ⅱ score was moderately correlated with admission on the first day of admission and the third day of admission(P〈0. 01）,and the mortality was highly correlated with the APACHE Ⅱ score on the fifth day of admission(P〈0. 01）. Conclusion The study provided a basis for the early disease evaluation of critically ill Uighur patients by measuring the correlation between serum RBP and APACH Ⅱ score of Uighur critically ill patients.