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重组人脑利钠肽对急性心肌梗死后心力衰竭老年患者炎性因子及心功能的影响 被引量:4

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摘要 目的观察重组人脑利钠肽对急性心肌梗死后心力衰竭老年患者炎性因子及心功能的影响。方法选取医院收治的急性心肌梗死后心力衰竭患者80例,随机分为观察组和对照组,每组40例。对照组实施抗血小板、抗凝、调脂、利尿、扩血管、改善心功能等内科常规治疗,观察组在对照组治疗基础上给予重组人脑利钠肽治疗。比较2组患者心功能、炎性因子水平以及不良事件发生率。结果治疗前,2组LVEF、HR、BNP、TNF-α、Hs-CPR水平比较差异无统计学意义(P>0.05);治疗后,观察组LVEF水平明显高于治疗前和对照组,HR、BNP、TNF-α和Hs-CPR水平明显低于治疗前和对照组治疗后(P均<0.01)。1年后,观察组心血管不良事件和心源性死亡发生率低于对照组(P<0.05或P<0.01)。结论重组人脑利钠肽能显著改善急性心肌梗死后心力衰竭老年患者心功能,降低炎性因子水平,延长患者生存时间,改善患者预后,值得临床推广使用。
作者 郑婕 张银虎
出处 《临床合理用药杂志》 2018年第14期28-29,共2页 Chinese Journal of Clinical Rational Drug Use
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