长非编码RNA在肿瘤耐药发展中的作用

Role of long non.coding RNA in tumor drug resistance development

随着长非编码RNA （lncRNA）的作用与种类被不断地研究与阐明,lncRNA与肿瘤耐药的关系越来越受到关注.研究发现lncRNA通过改变DNA修复与细胞周期、药物外排系统、药物代谢、细胞凋亡和上皮间质转化等过程参与肿瘤耐药.lncRNA有望成为新的生物学标志物,为肿瘤的诊断、治疗和预后评估提供新的途径.

With the continuous research and elucidation of the role and species of long non-coding RNAs （lncRNAs）,the relationship between lncRNAs and cancer resistance has been paid more and more attention by researchers.Studies find that lncRNAs are involved in tumor drug resistance by altering DNA repair and cell cycle,drug delivery system,drug metabolism,cell apoptosis and epithelial interstitial transformation.lncRNAs are expected to be a new biological marker,which provids a new way to diagnose,treat and evaluate the prognosis of cancer.