吉林大学第一医院小儿风湿免疫科住院患者超说明书用药分析

On Off-label Drug Use by Inpatients of Rheumatology and Immunology Department in the First Hospital of Jilin University

目的:回顾性调查小儿风湿免疫科住院患者超说明书用药情况,为规范儿科用药提供依据。方法:随机抽取吉林大学第一医院2014年9月-2015年9月小儿风湿免疫科300例住院患者病历,根据药品说明书判断是否为超说明书用药,并对超说明书用药的数量及类型分别进行统计分析。结果:随机抽取的300例住院患者超说明书用药发生率为96%。其中,用药医嘱超说明书用药发生率28.79%;涉及药品212种,超说明书用药发生率44.81%。超说明书用药类型以超适应人群(78.21%)所占比例最大。结论:我院小儿风湿免疫科存在超说明书用药现象,应加强超说明书用药的规范管理,促进儿科安全合理用药。

Objective： To retrospectively analyze the off-label drug use by inpatients in Pediatric Rheumatology and Immunology Department of the First Hospital of Jilin University and to provide references for rational drug use. Methods： The medical records of 300 inpatients in this hospital from September 2014 to September 2015 were randomly selected. The off-label drug use was judged according to package inserts. Moreover, the number and kinds of off-label drug use were statistically analyzed. Results： The incidence of off-label drug in 300 inpatients was 96%, among which 28.79% was prescription off-label drug use involving 212 kinds of drugs（accounting for 44.81%）. Over-appropriate population had the highest incidence（accounting for 78.21%）. Conclusion： Off-label drug use existed in Pediatric Rheumatology and Immunology Department of our hospital. We should strengthen standard management of off-label drug use and promote safe and rational drug use.