颅外肿瘤立体定向适形放射治疗40例分析

Stereotactic Conformal Radiotherapy of Extracranial Tumors

目的:报告立体定向适形放射治疗颅外肿瘤的结果并做临床分析。方法:1997年5月～1998年7月治疗46例颅外肿瘤(42个病变)并进行了随访。肿瘤的临床靶体积从0.2～232cm^3(平均29.7cm^3),对计划靶体积的最小放射剂量每次3.12～11.8Gy,分1～10次照射,最大剂量为4.00～15.00Gy(平均6.63Gy),处方剂量是3～12Gy(平均5.32Gy)。结果:治疗期间无病人死亡。患者的KPS评分:治疗前10～90(平均62),治疗后20～100(平均80)。实体瘤疗效标准:完全缓解(CR)9例,部分缓解(PR)23例,无变化(NC)3例,进展(PD)5例。随访114个月期间,观察到87.5%的肿瘤得到控制。80%的肿瘤缩小或消失。结论:立体定向适形放射治疗颅外肿瘤有良好疗效。

Objective:To report and analyze the effects of stereotactic conformal radiotherapy for extracranial tumors. Methods: Forty patients with extracranial tumors underwent stereotactic conformal radiotherapy from May of 1997 to July of 1998. The clinical target volume of tumors ranged form 0.2 to 232 cm3 with a mean of 2.97 cm3 , the minimal irradiation dose to the planning target volume (PTV) was 3.12-11.8 Gy/fraction which was applied within 1-10 times.The maximal irradiation dose to PTV ranged from 4.00 to 15.00 Gy with a mean of 6.63 Gy. The prescribed dose (PD) was 3-12 Gy (mean, 5.32 Gy). Results: No patient died during treatment. KPS score ranged from 10 to 90 (mean, 62) before treatment, and from 20 to 100 (mean, 80) after treatment. Tumor was completely remittent in 9 cases, partly remittent in 23 cases, no changed in 3 cases,and deteriorated in 5 cases.During the period of follow-up (1-14 months) ,87.5% of tumors were controlled, and 80% diminished or disappeared. Conclusion:Stereotactic conformal radiotherapy is an effective method in treating extracranial tumors.