小檗碱治疗代谢性疾病抗炎作用的研究进展

Research progresses of the anti-inflammatory activity of berberine in the treatment of metabolic diseases

慢性非可控性炎症在代谢性疾病如糖尿病、非酒精性脂肪性肝病(NAFLD)和动脉粥样硬化的发生和发展过程中发挥关键作用。天然产物小檗碱对代谢性疾病有良好的改善作用并对其伴随的慢性炎症有明显的抑制作用。研究显示小檗碱主要通过调控AMP依赖的蛋白激酶(AMPK)、核转录因子-κB(NF-κB)和肠道菌群来发挥抗炎活性。对小檗碱抗炎作用的深入研究将为其应用于临床治疗代谢性疾病提供进一步科学依据。

Chronic noncontrollable inflammation is crucial for the onset and development of metabolic diseases such as diabetes mellitus, nonalcoholic fatty liver disease （NAFLD）, and atherosclerosis. The natural product berberine has favorable improving activities on metabolic diseases and has significant inhibitory activities on chronic inflammation accompanied. The studies showed that the anti-inflammatory activity of berberine was mainly associated with the modulation of AMP-activated protein kinase （AMPK）, nuclear factor-κB （NF-κB）, as well as the gut microbiota. The in-depth investigation of the anti-inflammatory activity of berberine will provide further scientific evidences for its clinical application to treat metabolic diseases.