阿折地平的药动学和临床研究进展

Research progresses on pharmacokinetic and clinical application of Azelnidipine

阿折地平作为第3代二氢吡啶类钙拮抗剂,不仅显示出独特的降压优势,还具有减慢心率、抗动脉粥样硬化、心肾保护、改善胰岛素耐受、降低尿酸、减轻肝硬化等药理作用,具有较高的临床应用价值。查阅国内外相关文献,综述阿折地平的结构特征、药动学和临床研究进展,以期为临床合理用药及深入研究提供依据。

Azelnidipine as one of the third generation dihydropyridine type calcium channel blockers has high clinical value, it not only shows the unique advantage of antihypertension, but also shows the pharmacological action of heart rate slowing, anti-atherosclerosis, cardiorenal protection, insulin resistance improving, uric acid lowering, hepatic fibrosis alleviating, and so on. This article reviews its structure characteristics, pharmacokinetic and clinical research progresses in the related literatures published at home and abroad, with view to providing a basis for Azelnidipine on clinical rational drug use and deep exploration.