破裂风险指数预测腹主动脉瘤破裂的一项meta分析

Rupture potential index/peak wall rupture risk index predicts the rupture of abdominal aortic aneurysms: a meta-analysis

目的探讨破裂风险指数(rupture potential index/peak wall rupture risk index,RPI/PWRR)预测腹主动脉瘤(abdominal aortic aneurysm,AAA)破裂潜能的可能性。方法 2016年5月1日,通过系统检索Pubmed、Embase和Cochrane电子数据库,将所有基于有限元分析(finite element analysis,FEA)的比较破裂/有症状AAA(ruptured/symptomatic AAA,rAAA/s AAA)组、无症状AAA(asymptomatic AAA,a AAA)组的RPI/PWRR差异的原始文献纳入本研究。在独立提取数据后,利用随机效应模型汇总分析标准均数差(standard mean difference,SMD)。结果 6篇原始研究共计纳入440例AAA患者,结果提示r AAA/s AAA组的破裂指数明显高于aAAA组,SMD为1.31,95%置信区间(confidence interval,CI)在0.82~1.80,P<0.001。结论 RPI/PWRR也许可以用于预测AAA破裂。

Objective To investigate the potentiality of rupture potential index/peak wall rupture risk index （RPI/PWRR） in estimating the risk of abdominal aortic aneurysm （AAA） rupture. Methods The Pubmed, Embase and Cochrane electronic database were searched on May 1, 2016. All observational studies assessing RPI/PWRR in asymptomatic intact （aAAA） and acute ruptured or symptomatic AAA （rAAA/sAAA） by finite element analysis （FEA） were included. Random-effects model was used to calculate standard mean difference （SMD） for RPI/PWRR. Results Six studies including total 440 AAA patients were enrolled in this meta-analysis, the results of which showed that RPI/PWRR of rAAA/sAAA was significantly higher than that of aAAA （SMD： 1.31, 95% confidence interval： 0.82-1.80; P〈0.001）. Conclusion RPI/PWRR may be able to predict the rupture risk of AAA.