冠心病患者药物使用研究与方法学评价

Drug use research of patients with coronary heart disease and methodological evaluation

目的分析冠心病患者药物使用情况研究的初步结果,并比较文献研究和数据库研究在研究结果和研究方法上的差异。方法检索Pub Med、EMbase、Cochrane Library、万方数据库、中国知网、中国生物医学文献数据库中关于中国冠心病患者接受药物治疗的相关文献,截至2015-11-28,用Excel 2011进行统计文献研究的结果。提取研究数据库中冠心病患者用药信息,用SPSS 21.0和Excel 2011统计数据库研究的结果。比较2项研究的研究结果和研究方法。结果文献研究结果显示,抗血小板药物、β受体阻滞药、他汀类、血管紧张素转化酶抑制药(ACEI)和血管紧张素Ⅱ受体拮抗药(ARB)的药物使用率分别为90.62%,65.38%,73.94%,43.56%和19.95%。数据库分析结果显示,抗血小板药物、β受体阻滞药、他汀类、ACEI和ARB的药物使用率分别为77.40%,53.60%,68.60%,27.00%和26.00%。与数据库研究相比,二次文献研究具有样本量大、成本低、获取迅速等特点。结论药物流行病学研究方法各有优缺点,原始研究足够的情况下可用二次文献研究分析药物流行病学特征。

Objective To report the preliminary results of drug use in patients with coronary heart disease,and to compare the differences of research results and methodologies between literature research and database research. Methods Pub Med,EMbase,Cochrane Library,Wanfang data base,CNKI and CBM,were searched to collect all related literatures from beginning to November 28,2015. Data extracted from each individual study were analyzed using Excel 2011; patients with coronary heart disease from the database of a real word study were screened,and the drug use of patients with coronary heart disease was analyzed using SPSS21. 0 and Excel 2011. Results The literature research showed that the utilization rates of antiplatelet drugs,β-blocker,statins,angiotensin converting enzyme inhibitors(ACEI） and angiotensin receptor blocker(ARB） were 90. 62%,65. 38%,73. 94%,43. 56% and 19. 95% respectively; the database analysis showed that the utilization rate of antiplatelet drugs,β-blocker,statins,ACEI and ARB were 77. 40%,53. 60%,68. 60%,27. 00% and 26. 00%,respectively. Compared with database research, literature research has the characteristics of large sample size,low cost and fast acquisition. Conclusion There are both advantages and disadvantages in all the research methods of drugepidemiology,and literature researches can be used for pharmacoepidemiological study if there is enough original researches.