挥发性有机物致呼吸系统损害的流行病学研究综述

Respiratory system impairments induced by volatile organic compounds:An epidemiological review

挥发性有机物(volatile organic compounds,VOCs)是一类有机化合物,也是职业场所和室内外空气中常见的污染物。呼吸道是VOCs进入人体的主要途径,VOCs可在呼吸系统吸收和蓄积,并直接引起呼吸系统损害。既往研究提示,VOCs暴露与肺功能下降、哮喘、慢性阻塞性肺疾病和肺癌等多种呼吸系统病损有关,但危害程度并不一致。本文综述了近年VOCs暴露所致呼吸系统损害的人群流行病学研究,为今后进一步研究VOCs的健康损害提供思路。

Volatile organic compounds（VOCs）,a large class of organic compounds,are common air pollutants in workplace and indoor and outdoor environment.VOCs enter human body mainly through respiratory tract and accumulate in respiratory system,causing respiratory system damage directly.Previous studies show that VOCs exposure was associated with a variety of respiratory system lesions to varied extents,including lung function decline,asthma,chronic obstructive pulmonary disease,and lung cancer.This review summarized published population-based epidemiological studies about the association between VOCs and respiratory system impairments,aiming to provide new insights for further research in this area.