摘要
哮喘是一种慢性气道炎症性疾病,反复的炎症损伤与组织修复可导致气道重塑。气道上皮间质转化(epithelial mesenchymal transition,EMT)在哮喘的气道重塑中发挥了重要作用。转化生长因子β,核因子‐κB和溴结构域蛋白4等多种细胞因子及信号通路参与了EMT的分子调控。
Asthma is a chronic infl ammatory disease of the airway. Repeated infl ammatory injury and tissue repair can lead to airway remodeling. Th e airway epithelial mesenchymal transformation （EMT） plays an important role in airway remodeling of asthma. Various cytokines and signaling pathways, such as transforming growth factor β （TGF-β）, nuclear factor-kappa B （NF-κB） and bromodomaincontaining protein 4 （BRD4）, are involved in the molecular regulation of EMT.
作者
朱晓华
李秋根
ZHU Xiaohua;LI Qjugen(Graduate School of Nanchang University;Department of Respiratory Disease, Jiangxi Provincial Children＇s Hospital;Department of Respiratory Disease, Jiangxi Provincial People＇s Hospital, Nanchang 330006, China)
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2018年第5期566-570,共5页
Journal of Central South University ：Medical Science
基金
江西省科技厅重大科研基金(20151BBB70267)~~
关键词
哮喘
气道重塑
上皮间质转化
分子调控
asthma
airway remodeling
epithelial mesenchymal transition
molecular regulation
