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可切除胰腺癌新辅助治疗与直接手术的选择与争议 被引量:3

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摘要 胰腺癌是高度恶性的消化系统肿瘤,起病隐匿,预后差,其肿瘤相关病死率位居第4位.30年来,随着外科手术技术的不断进步,尽管胰腺癌围手术期病死率及术后并发症发生率明显下降,胰腺癌患者的总体生存时间仍无大幅度提升.约80%的患者在确诊时已失去手术机会,而对于可切除胰腺癌,其术后5年生存率仅约为20%.随着胰腺癌治疗理念的转变,胰腺癌的新辅助治疗逐渐受到关注.美国国立综合癌症网络(National Comprehensive Cancer Network,NCCN)指南推荐所有可能切除的胰腺癌患者行新辅助治疗,而对于可切除胰腺癌是否应用新辅助治疗或直接手术尚存在争议.本文将结合可切除胰腺癌新辅助治疗的相关研究,总结可切除胰腺癌新辅助治疗的提出背景、适应证及临床意义,比较新辅助治疗与直接手术对胰腺癌患者预后的影响,并结合笔者的临床经验,讨论新辅助治疗与直接手术的选择与争议.
出处 《国际外科学杂志》 2018年第5期289-291,共3页 International Journal of Surgery
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  • 1Michele Reni.Neoadjuvant treatment for resectable pancreatic cancer: Time for phase Ⅲ testing?[J].World Journal of Gastroenterology,2010,16(39):4883-4887. 被引量:2
  • 2SIEGEL R, MAJ, ZOU Z, et al. Cancer statistics, 2014[J]. CA CancerJ Clin, 2014, 64( 1) : 9 -29.
  • 3PISTERS PW, ABBRUZZESEJL,JANJAN NA, et al. Rapid - fractionation preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for resectable pancreatic adenocarcinoma[J].J Clin Oncol , 1998, 16 (12): 3843 -3850.
  • 4STALEY CA, LEEJE, CLEARY KR, et al. Preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for adenocarcinoma of the pancreatic head[J]. AmJ Surg, 1996, 171 ( 1 ) : 118 -124.
  • 5TALAMONTI MS, SMALL WJr, MULCAHY MF, et al. A multi - institutional phase II trial of preoperative full - dose gemcitabine and concurrent radiation for patients with potentially resectable pancreatic carcinoma[J]. Ann Surg Oncol, 2006, 13 (2): 150-158.
  • 6BRESLIN TM, HESS KR, HARBISON DB, et al. Neoadjuvant chemoradiotherapy for adenocarcinoma of the pancreas: treatment variables and survival duration[J]. Ann Surg Oncol, 2001,8(2): 123 -132.
  • 7HOFFMANJP, LIPSITZ S, PISANSKY T, et al. Phase II trial of preoperative radiation therapyand chemotherapy for patients with localized, resectable adenocarcinoma of the pancreas: an Eastern Cooperative Oncology Group Study[J].J Clin Oncol, 1998, 16(1): 317 -323.
  • 8COLBERT LE, HALL WA, NICKLEACH D, et al. Chemoradiation therapy sequencing for resected pancreatic adenocarcinoma in the National Cancer Data Base[J]. Cancer, 2014, 120(4): 499 -506.
  • 9SPITZ FR, ABBRUZZESEJL, LEEJE, et al. Preoperative and postoperative chemoradiation strategies in patients treated with pancreaticoduodenectomy for adenocarcinoma of the pancreas[J].J Clin Oncol, 1997, 15(3) : 928 -937.
  • 10GILLEN S, SCHUSTER T, MEYER ZUM SUSCHENFELDE C, et al. Preoperative/ neoadjuvant therapy in pancreatic cancer: a systematic review and meta -analysis of response and resection percentages[J]. PLoS Med, 2010, 7 (4): e1000267.

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