摘要
梭菌是肠道一大类兼性厌氧细菌,与许多疾病息息相关.其中艰难梭菌和产气荚膜梭菌主要通过产生毒素和气体诱发腹泻.临床主要通过酪酸梭菌、普拉梭菌等益生菌、梭菌疫苗、抗生素以及粪菌移植等手段抑制有害梭菌的增殖,恢复肠道菌群平衡治疗梭菌感染性腹泻.本文主要阐述肠道梭菌对腹泻机理的影响和治疗作用,为探索肠道梭菌感染性腹泻的治疗提供研究思路.
cultatiClostridium is a group of fave anaerobic bacteria in the intestinal tract and is closely related to many diseases. By producing toxins and gas, Clostridium difficile and Clostridium perfringens can induce diarrhea. Clostridium butyricum, Faecalibacterium prausnitzii and other probiotics, Clostridium toxin vaccine, antibiotics, fecal bacteria transplantation, and other means are the main methods which are clinically used to inhibit the proliferation of harmful Clostridium and restore the balance of intestinal flora. In this paper, we will review the role of intestinal Clostridium in the pathogenesis and treatment of diarrhea to promote the exploration of new therapeutic methods for diarrhea caused by intestinal Clostridium infection.
作者
郭艳芳
舒兰
谭周进
Yan-Fang Guo;Lan Shu;Zhou-Jin Tan(the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China;Department of Microbiology, Hu＇nan University of Chinese Medicine, Changsha 410208, Hunan Province, China)
出处
《世界华人消化杂志》
CAS
2018年第12期693-699,共7页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.81173214~~
关键词
艰难梭菌
产气荚膜梭菌
酪酸梭菌
普拉梭菌
腹泻
Clostridium difficile
Clostridium perfringens
Clostridium butyricum
Faecalibacterium prausnitzii
Diarrhea
