“细胞编程和重编程的表观遗传机制”重大研究计划结题综述

Review of the achievements of major research plan on“Epigenetic Mechanisms Underlining Cell Programming and Reprogramming”

国家自然科学基金委员会重大研究计划"细胞编程和重编程的表观遗传机制"历时8年于2017年完成结束评估。本文概述了该计划取得的研究进展,特别是在发现新的表观遗传调控因子和染色质重塑因子并揭示其生物学功能和作用机制,解析干细胞自我更新、体细胞重编程的调控机理及创建半克隆新方法,揭示表观遗传调控细胞分化转分化、个体发育及疾病发生发展的规律,以及从全基因组的层次上认识表观遗传网络形成和运行的机制等方面取得一系列突破性研究成果,产生了重要国际影响。文中展望了表观遗传学研究的发展态势,提出了未来关注的重点学术方向。

The NSFC major research plan of epigenetic mechanism underlining cell programming and reprogramming has experienced 8 years and terminated in 2017. This paper summarized the research progress of this plan and presented a series of breakthrough research achievements, such as discovering new epigenetic regulation factors and chromatin remodeling factors, interpreting their biological function and acting mechanism, giving new insights into the regulation mechanism of stem cell self-renewal and somatic cell reprogramming, creating novel methods of haploid embryonic stem cell induction and semi-cloning, revealing the epigenetic regulation mechanism of cell differentiation and trans-differentiation, individual development and disease incidence, and understanding epigenetic network and its operation in whole genome level. This paper also prospected the development of epigenetic research and put forward some key academic fields that should be pay more attention to in future.