IL-17在肾脏疾病中的研究新进展

New progress in the study of IL-17 in renal diseases

白介素17(IL-17)是一种促炎的细胞因子,由活化的CD4^+T细胞亚群(Th17)产生。它可以调节许多细胞的功能,参与炎症、自身免疫、肿瘤性疾病的发病过程。IL-17家族由6种家庭成员组成,分别是IL-17A,IL-17B,IL-17C,IL-17D,IL-17E和IL-17F。IL-17受体家族由5种成员组成,它们分别是IL-17RA、IL-17RB、IL-17RC、IL-17RD和IL-17RE。本文简单介绍IL-17家族、IL-17受体家族以及Th17/IL-17轴,并对IL-17在各种肾脏疾病中的新近研究进行概述。

Interleukin （IL）17 is a pro-inflammatory cytokine produced by the activated CD4^＋ T cell subsets （Thl7）. It can regulate the function of cells involving in the pathogenesis of inflammation, autoimmune, neoplastic disease. The IL-17 family consists of six family members, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F, respectively. The IL-17 receptor family consists of five members, IL-17RA, IL-17RB, IL-17RC, IL-17RD and IL-17RE, respectively. This review summarizes the characteristics and functions of the IL-17 family, the IL-17 receptor family, and the Th17/IL-17 axis. It also reviews the research about IL-17 in various kidney diseases.