富自体浓缩生长因子联合Bio-Oss骨粉在颌骨囊肿中的疗效研究

Efficacy of concentrated growth factors combined with Bio-Oss in the treatment of bone defect after jaw cyst surgery

目的评价使用富自体浓缩生长因子联合Bio-Oss(deproteinized bovine bone mineral)骨粉填充颌骨囊肿术后中、大型骨缺损的临床疗效,为其推广应用提供参考依据。方法选取2016年7月—2017年10月颍上县人民医院口腔颌面外科收治的30例颌骨囊肿术后中、大型骨缺损患者作为研究对象,采用富自体浓缩生长因子联合Bio-Oss骨粉填充骨腔,富自体浓缩生长因子压制成膜双层覆盖在骨缺损区表面。术后分别于第3、6、12个月进行定期观察随访,通过临床和影像学检查评估其疗效。结果 30例颌骨缺损修复患者术后伤口均为Ⅰ期甲级愈合,无一例出现术后感染和排异反应。影像学检查显示术后3个月可见骨腔内大量新骨形成,骨缺损区较术前明显缩小;术后6个月可见新骨密度增高,骨腔内有大量骨小梁形成,新骨与周围骨质界限模糊;术后12个月可见植骨区与周围颌骨组织密度接近,界限基本消失,连续性完整,充填材料与新生骨及周围骨组织生长良好,骨缺损区完全修复,表现出良好的软组织及骨组织修复效果。结论富自体浓缩生长因子联合Bio-Oss骨粉填充颌骨囊肿术后中、大型骨缺损区可有效促进骨组织修复和软组织愈合,有望作为一种新型、有效的颌骨缺损修复方式推广应用于临床。

Objective To observe the clinical effect of concentrated growth factors （CGF） combined with Bio-Oss in the treatment of bone defect after jaw cyst surgery, and to provide reference for its popularization and application. Methods A total of 30 cases of medium and large bone defect after jaw cyst surgery in our hospital between July, 2016 and October, 2017 were selected and treated with concentrated growth factors combined with Bio-Oss, The surface of bone defect was covered with double layer concentrated growth factors membrane. The postoperative follow-up was performed at third, sixth ,twelfth months after the operation, and the curative effect was evaluated by clinical and imaging examinations. Results All 30 cases were grade I healing after the operation. The imaging examination showed that a large number of new bone formed after 3 months, the bone defect area decreased obviously than preoperative, After 6 months, the new bone density was increased and a large number of bone trabeculae were formed, besides, the new bone was indistinct with the surrounding bone, After 12 months, the density of the bone area was close to the surroundings, the boundary disap- peared. The filling material, new bone and surroundings grew well, and the bone defect area was completely repaired, showing good soft tissue and bone tissue effect. Conclusion The concentrated growth factors combined with Bio-Oss can effectively repair the bone defect after jaw cyst surgery and promote soft tissue healing. It is expected to be a new and ef- fective way to apply in clinic.