深圳市乳腺癌患者Epstein—Barr病毒感染情况分析

Analysis of Epstein-Barr Virus Infection in Breast Cancer Patients in Shenzhen

【目的】了解深圳市乳腺癌患者Epstein-Barr病毒（EBV）感染情况。【方法】选择2015年6月至2016年1月深圳市人民医院收治的25例乳腺癌患者为研究对象（观察组），选择同期于本院检查为乳腺良性疾病36例患者为对照组。取其血清检测EBV早期抗原IgM、核心抗原IgG、衣壳抗原IgM、IgG、IgA，并对其结果进行统计分析。【结果】观察组中EBV核心抗原IgG阳性率为76．0％（19／25）、衣壳抗原IgG阳性率92．0％（23／25）、衣壳抗原IgA阳性率100％（25／25）；对照组的EBV核心抗原IgG阳性率86．1％（31/36）、衣壳抗原IgG阳性率97．2％（35／36）、衣壳抗原IgA的弱阳性率仅为19．4％（7／36）。衣壳抗原IgA和核心抗原IgG在两组间具有统计学意义（P〈0．01）。另观察组和对照组均未检测出Epstein-Barr病毒衣壳抗原IgM。【结论】乳腺癌及良性疾病患者曾感染EBV的感染率均较高，且乳腺癌患者衣壳抗原IgA阳性率明显高于乳腺良性疾病患者，EBV感染与乳腺癌发生可能存在一定的相关性，尚需进一步探讨。

[Objective] To study the Epstein-Barr virus infection in Breast Cancer Patients in Shenzhen. [Methods] Twenty-five patients with breast cancer admitted to Shenzhen peoples Hospital from June 2015 to January 2016 were selected as study objects （observation group） and 36 patients with benign breast diseases （control group）. EBV early antigen IgM, core antigen IgG and eapsid antigen IgG were detected in their serum, and the results were analyzed statistically. [Results]In the observation group, the positive rate of EBV core antigen （IgG） was 76.0 % （19 / 25）, the positive rate of capsid antigen （IgG） was 92. 0% （23/ 25）, and the positive rate of capsid antigen （IgA） was 100% （ 25 / 25）. In the control group, the positive rate of EBV core antigen （IgG） was 86.1% （31/36）, and the positive rate of capsid antigen （IgG） was 97.22 % （35 / 36）. The weak positive rate of capsid antigen （IgA） was only 19.4%. Capsid antigen IgA and core antigen IgG had statistical significance between the two groups （ P 〈0.01）. In addition, no Epstein-Barr capsid antigen IgM was detected in the observation group and the control group.[Conclusion]The infection rate of EBV in patients with breast cancer and benign diseases is higher, and the positive rate of capsid antigen IgA in breast cancer patients was significantly higher than that in patients with benign breast diseases. There may be some correlation between EBV infec tion and breast cancer, which needs further study.