左旋多巴联合卡巴拉汀治疗对帕金森病患者肌强直及多巴转运体的影响

Effect of Levodopa Combined with Rivastigmine on Myotonia and Dopa Transporter in Patients with earkinson＇s Disease

【目的】研究左旋多巴（L-dopa）联合卡巴拉汀治疗对帕金森病（Parkingson’s disease，PD）患者肌强直及多巴转运体影响。【方法】选择本院收治的早期帕金森患者101例，随机分为对照组（50例）和观察组（51例）。对照组患者给予L—dopa进行治疗，观察组给予L—dopa联合卡巴他汀治疗，连续治疗6个月。比较两组PD严重程度、平衡功能、PD级别、临床症状改善时间、多巴胺转运体放射计数及两组患者不良反应发生情况。【结果】治疗后，观察组患者PD严重程度评分UP-DRS（unified Parkingson’s disease rating scale，Up-DRS）低于对照组患者（P〈0．05）；Berg平衡功能评分高于与对照组（P〈0．05）；帕金森Hoehm-Yahr分级情况低于对照组患者（P〈0．05）；肌强直、静止性震颤及运动迟缓等症状缓解时间低于对照组（P〈0．05）；基底节（basal ganglia，BG）与枕叶（occipital lobe，Oc）比值均有增加趋势，但对照组发病对侧高于治疗前（P〈0．05）；观察组不良反应发生率低于对照组（P〈0．05）。【结论】L—dopa联合卡巴拉汀能够减轻PD症状，改善患者平衡能力，降低PD患者不良反应。

[Objective]To study the effect of levodopa combined with rivastigmine on myotonia and dopa transporter in patients with Parkinson＇s disease （PD）. [Methods] A total of 101 patients with early Parkinson disease treated in our hospital were randomly divided into control group （ n = 50） and observation group （ n = 51）. Patients in the control group were treated with levodopa, and patients in the control group were treated with levodopa plus rivastigmine in continuous treatment for 6 months. Parkinson＇s severity, balance function, Parkinsoffs grade, clinical symptom improvement time, dopamine transporter radiation count and adverse reactions were compared between the two groups. [Results]After treatment, UP-DRS （UP-DRS） in the obser vation group was lower than that in the control group （ P 〈0.05） ; Berg balance score higher than that of the control group （ P 〈0.05） ; Parkinsoffs Hoehn-Yahr classification was lower than that of the control group （ P 〈0.05） ; Myotonic stiffness, resting tremor and bradykinesia were shorter than those in the control group （ P〈0.05）. The ratio of basal ganglia （BG） to occipital lobe （OC） tended to increase, but the incidence of contra lateral control group was higher than that before treatment （ P 〈0.05）. The incidence of adverse reactions in the observation group was lower than that in the control group （ P 〈0.05）. [Conclusion] Levodopa combined with rivastigmine can alleviate the symptoms of PD, improve the balance ability of patients and reduce the adverse reactions in patients with Parkinson＇s disease.