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食管鳞癌miRNA-31表达与临床因素相关分析

The correlation between miRNA-31 expression in esophageal squamous cell carcinomas and the clinical factors
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摘要 目的食管鳞癌miRNA-31表达水平与各临床因素的关系分析。方法收集本院胸外科2012年1月-2013年1月手术切除的经病理医生确诊的食管鳞癌患者的癌组织以及相应癌旁组织冷冻标本40例,采用RT-PCR法检测各组织标本的miRNA-31表达水平,分析其与临床特征之间的关系。结果食管鳞癌组织miRNA-31相对表达量与癌旁组织表达量差异显著,具有统计学意义(P<0.05)。TNM分期(Ⅲ/Ⅳ)食管鳞癌的miRNA-31表达水平较TNM分期(Ⅰ/Ⅱ)明显上升,差异具有同意学意义(P<0.05)。局部浸润(T3/T4)食管鳞癌miRNA-31表达水平较局部浸润(T1/T2)明显上升(P<0.05)。结论食管鳞癌组织miRNA-31表达与食管鳞癌的转移性和TNM有关。 Objective We aim to analyze the relationship between miRNA-31 expression and clinical factors of esophageal squamous carcinoma. Methods Applying real-time RT-PCR,we investigated the miRNA-31 expression in 40 primary ESC specimens,along with the corresponding normal mucosa specimens,and analyze the relationship of their expression with clinic-pathological features. Results The miR-31 expression was up-regulated in ESC compared to normal mucosa(P = 0. 030). Furthermore,miR-31 expression in esophageal squamous carcinoma tissue with TNM stage Ⅲ/Ⅳ was higher than that in the tissue with TNM stage Ⅰ/Ⅱ(P〈0.05). The expression of miRNA-31 in T3/T4 local invasive carcinoma was significantly higher than that in T1/T2 local invasive carcinoma(P〈0.05).Conclusions The expression of miRNA-31 in esophageal squamous cell carcinoma is related to the metastasis of esophageal squamous cell carcinoma and TNM.
作者 易胜中 程桂荣 YI Sheng-zhong(Department of Thoracic Surgery of Hubei Cancer Hospital, Wuhan, Hubei, 430079, Chin)
出处 《齐齐哈尔医学院学报》 2018年第3期267-269,共3页 Journal of Qiqihar Medical University
关键词 食管鳞癌 miRNA-31 REAL-TIME RT-PCR Esophageal Squamous Carcinomas ESC MicroRNA-31 Real-time RT-PCR
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