组蛋白去甲基酶JMJD3在肿瘤发生发展中的作用

Roles of Histone Demethylase JMJD3 in Tumorigenesis

肿瘤的发生发展常常伴随着表观遗传的改变。组蛋白甲基化受表观遗传的调控,参与了多种生物学过程。JMJD3是一种组蛋白去甲基化酶,主要负责去除组蛋白H3第27位赖氨酸的甲基化修饰,在个体发育、衰老、炎症反应等过程中起到重要作用。近年研究发现,JMJD3在结肠癌、脑胶质瘤、乳腺癌等多种肿瘤中表达异常,并不同程度地影响了肿瘤的生长、迁移、侵袭等过程。该文对JMJD3在肿瘤发生发展中的作用及其潜在机制进行综述,以期靶向JMJD3为相关肿瘤的诊断与治疗提供新思路。

The development of tumors is often accompanied by epigenetic changes. Histone methylation was regulated by epigenetic regulation and was participated in a variety of biological processes. JMJD3, a histone demethylase, which was responsible for the removal of the methylation of di-and tri-methyl-lysine 27 on histone H3, plays important roles in the development of physiological process, such as individual development, senescence and inflammation. Recently, abnormal expressions of JMJD3 have been found in colon cancer, glioma, breast cancer and other tumors, which affect the growth, migration and invasion of these tumors to varying degrees. The role of JMJD3 in tumorigenesis and its underlying mechanisms was summarized so as to provide new ideas for the diag- nosis and treatment of related tumors through targeting JMJD3.