摘要大剂量甲氨蝶呤（High dose methotrexate,HD-MTX）可以使甲氨蝶呤（Methotrexate,MTX）在血液中达到较高的药物浓度,使MTX能够穿透血脑屏障,因此可以用于原发性中枢神经系统淋巴瘤（Primary central nervous system lymphoma,PCNSL）的治疗。但在HD-MTX提高抗肿瘤疗效的同时毒副作用也加大,比较常见的是消化道黏膜的损害、肝肾功能损害及骨髓抑制等。HD-MTX导致的急性肾功能不全临床发生率不高.
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