227例乙型肝炎病毒表面抗原阳性母亲所生儿童血清学调查

Serological survey of Hepatitis B virus in 227 cases of children born to HBs Ag positive mothers

目的调查乙型肝炎病毒表面抗原阳性母亲所生儿童的血清学检测现状,分析该类儿童感染乙肝的影响因素。方法调查郑州市三家医疗机构227名HBsAg阳性母亲所生儿童的喂养方式、主被动免疫情况、血清学特征。结果乙肝疫苗首针及时接种率为100.0%、全程接种率为100.0%,乙肝免疫球蛋白注射率为99.6%,保护性抗体HBsAb阳性率为83.7%,HBs Ag阳性率为2.6%,五项标志物全阴性者占11.9%;在喂养方式、疫苗剂量、注射乙肝免疫球蛋白情况不同时,五项标志物阳性率的差异无统计学意义(均为P>0.05)。结论相关医疗机构较好执行了国家免疫规划政策;在疫苗和免疫球蛋白联合免疫的前提下,母乳喂养不能确定为产后传播乙肝的影响因素。

Objective To investigate the current status of five markers of hepatitis B in children born to HBsAg positive mothers, and to explore the related factors of this kind children infected with hepatitis B after birth. Methods Surveying and obtaining feeding way,active or passive immunization, five markers of hepatitis B, from 227 cases of children born to HBs Ag Positive Mothers in three medical institutions in Zhengzhou in 2014. Results From subject of investigation,the first dose coverage rate timely for hepatitis B vaccine was 100.0 %,the all-course coverage rate for hepatitis B vaccine was 100.0 %, the coverage rate for anti-hepatis B immunoglobulin was 99.6 %,HBsAb positive rate was 83.7 %,HBsAg positive rate was 2.6 %,the proportion of five markers all negative was 11.9 %;There was no statistic difference in the positive rate of five markers of hepatitis B with different feeding ways, or different vaccine doses,whether anti-hepatis B immunoglobulin injected or not（all with P〉0.05）. Conclusions The relevant medical institutions have better implemented the national immunization program policy; Breast-feeding cannot be determined to be a related factor for infected with hepatitis B after birth, under the premise of vaccine and immunoglobulin combined immunization.