辛伐他汀联合阿司匹林治疗缺血性脑血管病的疗效观察

Observation on Efficacy of Simvastatin Combined with Aspirin in Treatment of Ischemic Cerebrovascular Disease

目的:探讨辛伐他汀联合阿司匹林治疗缺血性脑血管病的疗效。方法:选取2015年1月20日—2017年1月20日汉川市人民医院收治的缺血性脑血管病患者86例作为研究对象,以随机数字表法分为观察组和对照组,每组43例。观察组患者给予辛伐他汀联合阿司匹林治疗,对照组患者给予阿司匹林治疗。观察两组患者的临床疗效、神经功能缺损程度、脑血管事件复发情况及血脂水平。结果:观察组患者的总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗后,观察组患者美国国立卫生研究院卒中量表评分明显低于治疗前及对照组治疗后,差异有统计学意义(P<0.05);观察组患者脑血管事件复发率为11.63%(5/43),明显低于对照组的32.56%(14/43),差异有统计学意义(P<0.05);治疗后,观察组患者总胆固醇、低密度脂蛋白胆固醇水平明显低于对照组,高密度脂蛋白胆固醇水平明显高于对照组,差异均有统计学意义(P<0.05)。结论:辛伐他汀联合阿司匹林治疗缺血性脑血管病的疗效显著,可降低患者脑血管事件复发率。

OBJECTIVE： To probe into the efficacy of simvastatin combined with aspirin in treatment of ischemic cerebrovascular disease. METHODS： 86 patients with ischemic cerebrovascular disease admitted into Hanchuan People＇s Hospital from Jan. 20 th,2017 to Jan. 20 th,2018 were extracted to be divided into observation group and control group via the random number table,with 43 cases in each. The observation group was given simvastatin combined with aspirin,while the control group received aspirin. The clinical efficacy,neurological function deficiency scale,recurrence rate of cerebrovascular events and blood lipid level of two groups were observed. RESULTS： The total effective rate of observation group was significantly higher than that of control group,with statistically significant difference（ P〈0. 05）.After treatment,the National institutes of health stroke scale score of observation group was significantly lower than that of before treatment and control group after treatment,with statistically significant difference（ P〈0. 05）. The recurrence rate of cerebrovascular events of observation group was 11. 63%（ 5/43）,significantly lower than that of control group[32. 56%（ 14/43） ],with statistically significant difference（ P〈0. 05）. After treatment,the total cholesterol,low density lipoprotein cholesterol of observation group were significantly lower than those of control group,yet the high density lipoprotein cholesterol was significantly higher than that of control group,with statistically significant difference（ P〈0. 05）. CONCLUSIONS： The efficacy of simvastatin combined with aspirin in treatment of ischemic cerebrovascular disease is significant,which can reduce the recurrence rate of cerebrovascular events.