大蒜素对前列腺癌患者细胞免疫功能的影响

Effect of Allicin on Cellular Immune Function in Patients with Prostate Cancer

目的:观察大蒜素注射液对于治疗前列腺癌的临临床效果,进一步探讨其对于前列腺癌患者机体免疫功能的影响及其作用机制。方法:选取2016年7月至2017年2月新乡医学院第一附属医院住院治疗的前列腺癌患者92例,随机平均分成对照组和观察组,每组46例。2组均采取急促治疗,观察组在此基础上使用生理盐水与大蒜素注射液配制后静脉推注,2周为1个疗程,在治疗3个疗程再观察2组患者在临床疗效、临床功能评分、免疫水平以及前列腺液COX-2、p38MAPK、血浆TNF-α以及IL-6方面的变化。结果:1)治疗后观察组的有效率84.78%,对照组的有效率为67.39%,2组有效率差异有统计学意义(P<0.05);2)2组患者治疗前各评分差异无统计学,治疗后QOL均较治疗前降低,IIEF-5均升高,但观察组的QOL评分及IIEF-5评分的变化差异有统计学意义(P<0.05);3)在治疗前,2组前列腺癌患者免疫功能的水平差异无统计学意义(P>0.05),与治疗前比较,对照组在治疗前后无显著变化,观察组免疫功能指标均有显著的提高;4)治疗前,观察组与对照组前列腺液的COX-2、p38MAPK及血浆TNF-α、IL-6差异无统计学意义(P>0.05),在经过治疗后,观察组及对照组的上述指标均下降,且观察组的上述指标降低,差异有统计学意义(P<0.05)。结论:大蒜素注射液在治疗前列腺癌方面有显著的临床效果,该药可改善患者免疫功能,降低其前列腺炎性反应程度,值得推广。

Objective： To observe the clinical effects of allicin injection in the treatment of prostate cancer,and to explore the effects of the injection on the immune function and its mechanism. Methods： A total of 90 patients with prostate cancer who were admitted to our department from July 2016 to February 2017 were randomly divided into control group and observation group. The two groups were treated with rapid treatment,and the observation group was received allicin injection with saline intravenous injection based on that. 2 weeks for a course of treatment. After 3 courses of treatment,the clinical efficacy,the clinical function score,immune level and prostatic fluid p3. 8 MAPK,COX-2 and plasma IL-6,TNF-α levels and other changes of two groups were observed. Results： 1） The effective rate was. 86. 67% in the observation group and 6. 8. 89% in the control group. There was significant difference between the two groups（ P〈 0. 05）. 2） There was no significant difference between the two groups before treatment（ P 〉0. 05）. After treatment,the levels of QOL were lower than those before treatment,while IIEF-5 was increased. The changes of observation groups were more significant,and but the changes were statistically significant（ P 〈0. 05）. 3） There was no statistically significant difference in immune function in both groups before treatment（ P〉 0. 05）. After treatment,the immunological kinetic energy of the observation group was slightly higher than that before treatment,but there was no significant difference in control group. 4） There was no significant difference in the levels of p3. 8 MAPK,COX-2 and plasma IL-6 and TNF-α between the two groups before treatment（ P 〉0. 05）. After treatment,the above indexes were lower than those before treatment,but the observation group decreased more significantly（ P〈 0. 05）. Conclusion： Allicin injection in the treatment of prostate cancer has a significant clinical effect,and the drug can improve the immune function,reduce the degree of prostatitis inflammation,which is worthy of promotion.