针灸结合免疫抑制剂治疗对副肿瘤综合征患者相关抗体及肌电图指标的影响

Effects of Acupuncture Combined with Immunosuppressor on the Related Antibodies and Electromyogram Index in the Treatment of Paraneoplastic Syndrome Patients

目的:探究针灸结合免疫抑制剂治疗对副肿瘤综合征患者相关抗体及肌电图指标的影响。方法:选取2015年3月至2017年4月本溪钢铁公司总医院收治的副肿瘤综合征患者100例,随机分为对照组和观察组,每组50例。对照组患者给予免疫抑制剂规范化治疗,观察组患者在对照组的基础上联合中医针灸辨证治疗,2组均连续治疗4周。统计2组患者临床疗效;检测并比较治疗前后2组血清相关抗体水平及肌电图指标变化。结果:治疗后观察组总有效率为86.00%,较对照组的56.00%显著升高(P<0.01);与治疗前比较,治疗后2组血清抗Hu-抗体、抗-Yo抗体、抗-Ri抗体水平均显著降低(P<0.01),且观察组均显著低于对照组(P<0.01);与治疗前比较,治疗后2组患者正中神经及尺神经运动/感觉传导速度均显著加快(P<0.05或P<0.01),且观察组显著快于对照组(P<0.01);运动/感觉波幅显著增大(P<0.01),且观察组显著大于对照组(P<0.01)。结论:针灸结合免疫抑制剂治疗副肿瘤综合征可显著调节患者自身免疫紊乱,并有效改善患者肌电图,恢复其正常神经功能,临床疗效显著且优于免疫抑制剂单用。

Objective： To explore the effects of acupuncture combined with immunosuppressor on the related antibodies and electromyogram index in the treatment of paraneoplastic syndrome patients. Methods： A total of 100 cases of paraneoplastic syndrome patients in our hospital from March 2015 to April 2017 were selected and randomly divided into control group and research group,with 50 cases in each group. Control group patients were treated with immunosuppressor for standardized treatment and research group patients were treated with TCM acupuncture differential treatment on the basis of control group. Patients in the 2 groups were treated for 4 weeks continuously. The clinical effects of 2 groups were statisticsed; the levels of serum related antibodies and the changes of electromyogram indexes of 2 groups before and after treatment were detected and compared. Results： The total effective rate of research group after treatment was 86. 00%,which was higher than 56. 00% of control group significantly（ P〈 0. 01）;compared with before treatment,the serum anti-Hu antibody,anti-Yo antibody,anti-Ri antibody levels of 2 groups after treatment decreased significantly（ P 〈0. 01）,and the levels of research group were lower than those of control group（ P〈 0. 01）; compared with before treatment,the movement/sensory conduction velocity of median nerve and ulnar nerve of 2 groups before and after treatment quickened significantly（ P 〈0. 05 or P〈 0. 01）,and the velocity of research group was more quick than that in control group（ P 〈0. 01）; the movement/sensory amplitude increased significantly（ P〈 0. 01）,and amplitude in study group was greater than that in control group（ P 〈0. 01）. Conclusion： Acupuncture combined with immunosuppressor can adjust the autoimmune disorders of paraneoplastic syndrome patients,which can improve the electromyogram of patients,recover normal nerve function,enhance the clinical efficacy effectively,and is better than use immunosuppressor alone.