联用加味芍药汤与美沙拉嗪治疗溃疡性结肠炎的效果分析

Effect of combination of Jiawei Shaoyao Decoction and mesalazine for ulcerative colitis

目的 :探讨联用加味芍药汤与美沙拉嗪治疗溃疡性结肠炎(UC)的临床效果。方法 :选取2015年1月至2017年3月期间绵阳市安州区人民医院收治的90例溃疡性结肠炎患者作为研究对象。根据用药方案的不同,将这些患者平均分为美沙拉嗪组(n=45)和美沙拉嗪-芍药汤组(n=45)。为美沙拉嗪组患者使用美沙拉嗪肠溶片进行治疗,为美沙拉嗪-芍药汤组患者在使用美沙拉嗪肠溶片的基础上,加用加味芍药汤进行治疗。然后,比较两组患者的治疗效果、在接受治疗后其血清炎性因子的水平、不良反应的总发生率以及病情的复发率。结果 :接受治疗后,与美沙拉嗪组患者相比,美沙拉嗪-芍药汤组患者治疗的总有效率明显更高,其CRP(C-反应蛋白)的水平、TNF-α(肿瘤坏死因子-α)的水平、IL-1(白细胞介素-1)的水平、IL-8(白细胞介素-8)的水平和病情的复发率均明显更低,差异具有统计学意义(P<0.05)。两组患者不良反应的总发生率相比,差异无统计学意义(P>0.05)。结论:联合使用加味芍药汤与美沙拉嗪治疗溃疡性结肠炎的疗效确切。该用药方案值得在临床上推广和应用。

objective： to explore the clinical effect of combining the combination of paeonia and mealazine in the treatment of ulcerative colitis（UC）. Methods： 90 patients with ulcerative colitis were selected from January 2015 to March 2017 in the people＇s hospital of anzhou district, mianyang city. According to the differences in the drug regimen, the patients were divided into two groups： mealazine（n=45） and salazine（n=45）. For the beautiful salad oxazine group of patients with beautiful salad oxazine enteric-coated metformin hydrochloride treatment, for the beautiful salad oxazine-peony decoction group of patients in the use of the salad oxazine enteric-coated metformin hydrochloride, on the basis of combined with flavored peony decoction treatment. Then, the therapeutic effect of the two groups was compared, the level of serum inflammatory factors, the total incidence of adverse reactions and the recurrence rate of the disease were compared. Results： after treatment, and the salad oxazine group of patients, compared to the salad oxazine-peony decoction group total effective rate of treatment in patients with significantly higher, the CRP（C-reactive protein） level, the TNF alpha（tumor necrosis factor alpha） levels, IL-1（interleukin 1） levels, IL-8（interleukin-8） levels and disease recurrence rates were significantly lower, statistically significant difference（P〈0.05）. There was no statistically significant difference in the total incidence of adverse reactions between the two groups（P〈0.05）. Conclusion： it is very effective to treat ulcerative colitis with the combination of flavoring peony soup and mesalazine. The drug regimen is worthy to be popularized and applied clinically.