妊娠期血脂水平与早产发生的相关性研究

Correlation between blood lipid level during pregnancy and the occurrence of preterm delivery

目的通过分析早产孕妇与足月孕妇血脂4项指标的变化,探讨血脂水平与早产发生的关联。方法选取2014年8月至2017年4月在西北妇女儿童医院产科孕检及分娩的妊娠28~36+6周的早产患者119例作为病例组,以同期正常足月分娩的孕妇84例为对照组。比较病例组与对照组母血中的总胆固醇(TCHO)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL)的水平,分析病例组与对照组的妊娠结局差异。结果病例组的孕妇HDL水平较对照组显著降低(t=2.30,P<0.05)。病例组的孕妇TCHO、TG、LDL水平与对照组比较无显著性差异(t值分别为0.23、1.69、1.25,均P>0.05)。结论妊娠期血脂生理性升高,可以满足孕妇及胎儿的早产生理需求,HDL过低可能与早产发生有关。

Objective To explore the correlation of blood lipid level and preterm delivery by analyzing the changes of 4 indexes of blood lipid in preterm pregnant women and full term pregnant women. Methods A case-control study was conducted in 119 cases of preterm delivery at 28- 36＋6 gestational weeks from August 2014 to April 2017 in Northwest Women and Children Hospital. The control group included 84 pregnant women with normal full-term delivery. Maternal blood cholesterol （CHOL） , triglycerides （TG）, high density lipoprotein cholesterol （HDL）, and low density lipoprotein cholesterol （LDL） level were compared between normal full-term group and preterm delivery group, and the difference between two groups was analyzed. Results The HDL of the preterm delivery group was significantly lower than the normal delivery group （t = 2.30, P 〈0.05）. There were no significant differences in CHOL, TG and LDL between preterm delivery group and the full-term delivery group （t value was 0.23, 1.69 and 1.25, respectively, all P〈0.05）. Conclusion Physiological lipid level during pregnancy increases, which can meet the physiological needs of pregnant women and fetus. Low HDL may be associated with preterm delivery.