脉冲染料激光联合点阵激光治疗儿童毛细血管畸形的临床疗效观察

Clinical Efficiency of Pulsed Dye Laser Combined with Fractional Laser in the Treatment for Children Capillary Malformation by Dermoscopy Observation

目的对脉冲染料激光(PDL)联合点阵激光治疗儿童毛细血管畸形(鲜红斑痣PWS)的疗效进行临床分析。方法 19例受试者,同一解剖部位的每例设计3个区:A区为空白对照区;B区为PDL治疗区,C区为PDL联合点阵激光治疗区。治疗后3个月随访分析其临床疗效。结果医生主观评估中,B区和C区的平均评分分别为(1.5±0.41)分和(2.26±0.61)分。皮肤镜评估中,B区为(1.76±0.35)分,C区为(2.45±0.62)分,两种方法差异有统计学意义(P<0.05),两区均未出现明显不良反应。结论联合疗法疗效优于单纯的脉冲染料激光治疗,安全性高。

Objective To analyze the clinical efficacy of combination therapy of pulsed dye laser（PDL）and fractional laser for capillary malformationor PWS（port wine stains）in children. Methods The same anatomical positions of 19 subjects were divided into 3 areas： A was the control area, B was the PDL treatment area, and C was the treatment area for PDL combined with fractional laser. Subjects were followed up 3 months after their treatment. Results In terms of the subjective evaluation by doctors, area B and C respectively scored（1.5±0.41）and（2.26±0.61）points on average. However, according to the dermoscopic evaluation, the average scores of area B and C were（1.76±0.35）and（2.45±0.62）points respectively. The difference was statistically significant（P〈0.05）, and no adverse reactions were found in both areas. Conclusion The combination therapy outperforms the solo PLD therapy in terms of safety, and it is of bright prospect.