单一损害蕈样肉芽肿的临床特点和治疗进展

Clinical Features and Treatment of Unilesional Mycosis Fungoides

单一损害蕈样肉芽肿(unilesional mycosis fungoides,UMF)在1981年由Jones等首先报道,是蕈样肉芽肿(mycosis fungoides,MF)的少见临床亚型之一。UMF具有单一的皮肤损害,一般不超过体表面积的5%,皮损类型多样,还包含如单一损害的亲毛囊蕈样肉芽肿(unilesional folliculotropic mycosis fungoides,UFMF)等更少见的特殊类型,易误诊。UMF总体预后良好,目前多采用手术切除、放疗、光动力治疗等方法,完全缓解率高,但也有疾病进展及复发的报道。本文回顾了国内外报道的100余例UMF,围绕该病的临床特点及治疗方法作一综述,旨在为临床实践提供参考。

Unilesional mycosis fungoides（UMF）, which was first reported by Jones in 1981, is a rare subtype of mycosis fungoides（MF）. Clinically UMF is characterized by the presence of a solitary lesion that covers less than 5% of the body surface. UMF has diverse clinical manifestations, including some rare subtypes such as unilesional folliculotropic mycosis fungoides（UFMF）, which makes it easily misdiagnosed. Current treatment includes surgical excision, radiation therapy and photodynamic therapy, which result in high complete remission rates. Although the overall prognosis of UMF is good, disease progression and recurrence are also reported. Up to now more than 100 cases of UMF have been reported in literatures, and this article reviews the clinical features and treatment strategies of UMF, aiming to provide some references for clinical practice.