ER阳性乳腺癌根治术后辅助内分泌治疗的效果分析

Effect analysis of adjuvant endocrine therapy after radical mastectomy for ER positive breast cancer

目的探讨雌激素受体(ER)阳性乳腺癌根治术后辅助内分泌治疗的效果。方法 60例ER阳性乳腺癌根治术后患者,随机分为研究组和对照组,每组30例。研究组给予内分泌治疗,对照组给予化疗。比较两组患者,术后治疗6个月无病生存率、总生存率及治疗前后肿瘤指标[癌类抗原(CA)19-9、CA125]。结果研究组患者术后治疗6个月无病生存率、总生存率分别为90.0%、96.7%,均高于对照组的73.3%、83.3%,差异有统计学意义(P<0.05)。两组患者治疗前肿瘤指标比较差异无统计学意义(P>0.05)。研究组患者治疗后CA19-9、CA125指标均优于对照组,差异有统计学意义(P<0.05)。结论随着ER阳性乳腺癌发病率的增加,ER阳性乳腺癌患者术后采取辅助内分泌治疗可以提高治疗疗效,延长术后生存期。

Objective To discuss the effect of adjuvant endocrine therapy after radical mastectomy for estrogen receptor（ER） positive breast cancer. Methods A total of 60 ER positive breast cancer patients with radical mastectomy were randomly divided into research group and control group, with 30 cases in each group. The research group received endocrine therapy, and the control group received chemotherapy. Comparison were made on 6-month disease-free survival rate, overall survival, and tumor markers[ cancer antigen（CA） 19-9, CA125] before and after treatment between the two groups. Results The research group had higher 6-month disease-free survival rate and overall survival respectively as 90.0% and 96.7% than 73.3% and 83.3% in the control group, and their difference was statistically significant（P〈0.05）. Both groups had no statistically significant difference in tumor markers before treatment（P〉0.05）. The research group had better CA19-9 and CA125 indicators after treatment than the control group, and the difference was statistically significant（P〈0.05）. Conclusion With the increase of the incidence of ER positive breast cancer, adjuvant endocrine therapy for ER positive breast cancer patients can improve the treatment efficacy and prolong the survival period after operation.