老年性骨质疏松症患者脂代谢水平及临床意义探讨

Lipid metabolism levels of osteoporosis patients and investigation of clinical meaning

目的：探讨老年性骨质疏松症（OP）患者脂代谢水平及与OP的相关性.方法：选取本院收治OP老年患者55例,选择同期在本院体检健康者50例作为对照组.比较2组甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白（LDL-C）、高密度脂蛋白（HDL-C）、骨密度（BMD）及血清骨钙素（BGP）水平.分析OP患者TG、TC、LDL-C、HDL-C与其BMD、BGP的相关性.结果：OP组老年患者的TG、TC、LDL-C明显高于对照组,HDL-C、BMD、BGP明显低于对照组（P〈0.01）.OP骨折组老年患者TG、TC、LDL-C明显高于OP无骨折组,HDL-C、BMD、BGP明显低于OP无骨折组（P〈0.01）.经Spearman相关性分析,OP老年患者血清中TG、TC、LDL-C与BMD、BGP呈负相关,HDL-C与BMD、BGP呈正相关（P〈0.01）.结论：OP患者脂代谢异常可能影响骨代谢,对OP的发生发展有一定促进作用.

Objective：To investigate lipid metabolism levels of osteoporosis patients and the correlation with OP. Methods ：55 aged ca- ses with OP were selected in the hospital, and healthy examined people were chosen as control group. Triglyceride （ TG）, total cholesterol （TC）, low density lipoprotein （LDL- C ）, high -density lipoprotein cholesterol （HDL- C ）, bone mineral density bmd （BMD）, and serum bone glaprotein（BGP） were compared between two groups. Correlation between TG, TC, LDL - C, HDL - C and BMD and BGP was ana- lyzed in OP patients. Results： Levels of TG, TC, LDL - C of OP cases were obviously higher, while HDL - C, BMD, BGP were lower, than control group （ P 〈 0.01 ）. Levels of TG, TC, LDL - C of OP cases with fracture were remarkably higher, while HDL - C, BMD, BGP were lower, than OP cases without fracture （ P 〈 0.01 ）. Levels of TG, TC, LDL - C of cases with OP aged cases were negatively correlated with BMD and BGP,and HDL- C was positively correlated with BMD and BGP by Spearman correlation analysis（ P 〈 0.01 ）. Conclusion：Ab- mormal lipid metabolism levels of osteoporosis patients can affect bone metabolism,which promote occurrence and development of OP.