慢性牙周炎牙周基础治疗前后血清超敏C反应蛋白与单核细胞趋化蛋白-1变化研究

Influence of chronic periodontitis and periodontal therapy on sencm high-sensitivity C-reactive protein and monocyte chemoattractant protein-1

目的研究慢性牙周炎对血清超敏C反应蛋白(hs-CRP)和单核细胞趋化蛋白-1(MCP-1)浓度的影响。方法选取2015—2016年于中国人民解放军陆军总医院口腔科门诊就诊的80例牙周炎患者(牙周病组)和40名无牙周炎症状的志愿者(对照组)。初诊记录探诊出血(BOP)、牙周探诊深度(PD)和临床附着丧失(CAL)情况,收集空腹静脉血,检测血清超敏C反应蛋白(hs-CRP)和单核细胞趋化蛋白-1(MCP-1)。对牙周病组进行为期3个月的牙周基础治疗,治疗结束3个月后,再次收集空腹静脉血,检测血清hs-CRP和MCP-1。结果牙周病组与对照组基线条件无明显差异。对照组hs-CRP和MCP-1浓度为(1.48±1.1)mg/L和(42.3±4.9)mg/L,牙周病组分别为(3.89±2.8)mg/L和(88.7±5.8)mg/L,两组差异有统计学意义(P<0.05)。牙周治疗结束3个月后,牙周病组hsCRP和MCP-1浓度为(2.04±1.5)mg/L和(64.2±5.1)mg/L,与治疗前比较差异有统计学意义(P<0.05)。结论慢性牙周炎可引起低滴度菌血症,造成血清炎症标志物hs-CRP和MCP-1浓度增高,有效的牙周基础治疗可降低血清hs-CRP和MCP-1。

Objective This study compared circulating high-sensitivity C-reactive protein（hs-CRP）and monocyte chemoattractantprotein-1（MCP-1）in control individuals and patients with periodontal disease and observed whether nonsurgical periodontal therapy affected inflammatory disease markers after 3 months. Methods 40 controls and 80 patients with periodontal disease were selected.Periodontal parameters included probing depth,bleeding on probing,clinical attachment level,as well as the following inflammatory markers：high-sensitivity C-reactive protein（hs-CRP）and monocyte chemoattractant protein（MCP）-1. Results There were no differences in the hematologic parameters of the patients in the control and periodontal disease groups. Hs-CRP and MCP-1 concentrations were higher in theperiodontal disease group at baseline compared to the controls（P = 0.005 and P = 0.003,respectively）. A decrease in circulating hsCRP and MCP-1 concentrations was observed 3 months after therapy（P = 0.009 and P = 0.007,respectively）. Conclusion In apparently otherwise healthy patients,periodontal disease is associated with increased circulating concentrations of hs-CRP and MCP-1,which decreased 3 months after non-surgical periodontal therapy.