基于关联规则分析的“真实世界”复方苦参注射液治疗肺癌中西药联合应用特征研究

Association rules analysis of Fufang Kushen injection in combination with modern medications in treating lung cancer:real-world study based on hospital information

该研究基于中国中医科学院中医临床基础医学研究所建立的医院信息系统集成数据仓库,探索复方苦参注射液临床联合用药规律,针对其真实世界治疗肺癌的临床中西药联合应用规律进行分析,为提高临床用药合理性、探索治法模式及后续深入分析的开展提供参考借鉴。通过提取使用复方苦参注射液治疗肺癌患者电子医疗数据,分析西药联合用药频数分布特点,应用Apriori算法分析联合用药关联性。最终纳入49 597例符合要求的患者,常见联用的中药为活血化瘀药、健脾和胃药、理气剂、清热解毒剂、通便剂、益气扶正剂;常见联用西药为5-HT受体阻断药、抗生素类药、抗肿瘤化疗药、免疫调节药、糖皮质激素药、镇痛药。结果表明复方苦参注射液联用用药分布特征及关联规则呈现特定规律,符合基于现代医学与中医学的肺癌核心治疗策略,该结果为临床合理用药提供参考。

The present study was aimed to analyze the association rules of Fufang Kushen injection in combination with other modern medications in treating lung cancer based on the electrical medical records in real world clinical situations extracted from hospital information system in Institute of Basic Medical Sciences,China Academy of Chinese Medical Sciences,and provide reference for improving rationality of clinical drug use and exploring the prescription rules as well as subsequent in-depth analysis. The electrical medical records of the hospitalized patients using Fufang Kushen injection for lung cancer were extracted to analyze the frequency distribution characteristics in combined application with western medicine,and Apriori algorithm was used to analyze the specific association rules in combined drug use. A total of 49 597 patients were included in the study. The commonly combined modern medications included5-HT receptor blockers,antibiotics,chemotherapy drugs,antitumor immune regulating drugs,glucocorticoid drugs and analgesics,which was usually applied in combination with traditional Chinese medications such as those for removing blood stasis,spleen and stomach nourishing drugs,Qi-regulating agent,heat-clearing and detoxifying prescriptions,laxative and Qi invigorating agent in clinical treatment. The results revealed that the distribution characteristics in combined application and association combinations of Fufang Kushen injection had specific rules,consistent with the clinical orientation of this drug in treatment of lung cancer. Such results may provide reference for reasonable application of Fufang Kushen injection in clinical treatment.