基于数据挖掘技术的藏医药治疗高原病用药规律研究

Study on medication laws of Tibetan medicine in treatment of plateau disease based on data mining technology

该研究基于中医传承辅助平台（TCMISS）,分析《四部医典》《甘露本草明镜》等相关书籍中用于治疗高原病方剂的常用药物、药物组合频次、核心药物组合与新方药物组合等。应用TCMISS V2.5软件,构建藏医治疗高原病用药数据库,采用频数分析、关联规则Apriori算法、改进的互信息法等数据挖掘方法对药物配伍规律进行挖掘。对531首高原病方剂分析后,总结出高原病常见的症状有失眠、耳鸣等20种;高原病方剂中总共涉及539味药,其中药用频次≥50的有诃子、肉豆蔻等33味,以诃子药用频次最高;用于治疗高原病的常用药物组合14个,以＂木香-诃子＂使用频次最高;熵聚类分析演化得到核心药物组合13个,其中包括＂大蒜-藏茴香-阿魏＂等3味药组合8个,＂木香-沉香-丁香-肉豆蔻＂等4味药组成的核心组合5个,＂大蒜、藏茴香、阿魏、木香、广枣、沉香、肉豆蔻＂等新处方5个。选择主要症状＂失眠＂进行分析得出治疗失眠的以沉香、诃子、广枣等为主的核心药物组合和以红花、多刺绿绒蒿、石榴子为主的新方药物组合。通过TCMISS对用于治疗高原病的方剂进行统计分析,进一步总结高原病方的临床组方规律和常用药物组合特点,为其临床应用和新药研发提供参考与新思路。

Traditional Chinese medicine inheritance support system（ TCMISS,V2. 5） was used in this study to analyze the common medicines,frequency of medicine combination,core herbal combinations and new prescriptions for the treatment of plateau disease from the Four-Volume Medical Code,Mannose Herbal Mirror and other related books. TCMISS V2. 5 software was used to construct the database of drug treatment for plateau disease. The frequency analysis and association rules apriori algorithm,improved mutual information method and other data mining methods were used to explore the law of drug compatibility. After the analysis of 531 prescriptions for plateau disease,20 common symptoms of plateau disease were summarized such as insomnia and tinnitus. There were 539 kinds of herbs in the plateau disease prescriptions,including 33 kinds of herbs whose medicinal frequency≥50,such as Terminalia chebula and Myristica fragrans,and T. chebula had the highest medicinal frequency; 14 commonly used herbal combinations,and ＂ Aucklandia lappa-T. chebula＂ had the highest frequency; 13 core herbal combinations were obtained after entropy clustering analysis,including 8 combinations of three herbs such as ＂ Allium sativum-Carum carvi-Ferula sinkiangensis＂ and 5 combinations of four herbs such as ＂ A. lappa-Aquilaria sinensis-Ewgewia caryophyllata-Myristica fragrans ＂,and 5 new prescriptions such as ＂ A. sativum-C. carviF. sinkiangensis-A. lappa-Choerospondia axillaris-A. sinensis-M. fragrans＂. The main symptom of ＂ insomnia＂ was chosen to analyze the treatment of insomnia,and the core herbal combinations mainly including A. sinensis,T. chebula,and C. axillaris as well as the new prescriptions mainly containing Carthamus tinctorius,Meconopsis horridnla,and Punica granatum were obtained. The prescriptions for the treatment of plateau disease were clarified by TCM inheritance system,and the clinical prescription regularity and characteristics of the combination of common medicines were summarized,to provide reference and new ideas for its clinical application and develop-ment of new drug research.