线粒体自噬的研究进展

Advances in the Study of Mitophagy

线粒体自噬在细胞质量控制、发育等生理过程中起重要作用,线粒体自噬的异常会导致神经退行性疾病、心脏病、肿瘤等病理反应。线粒体自噬的关键步骤是待降解的线粒体和自噬泡这两个细胞器之间的特异性识别,该过程是通过位于线粒体上的降解信号和自噬泡上的受体相互作用来介导的。近年来,有多个线粒体自噬的受体识别通路陆续被发现,然而,在这些通路中线粒体自噬信号如何起始和调控尚不清楚。该文就线粒体自噬的最新研究进展作一简要综述,旨在为相关领域的研究提供参考。

Mitophagy plays an important role in mitochondria quality control and development. Mitophagy deficiency causes many diseases, including neurodegenerative diseases, heart diseases and cancer. The key step of mitophagy is the specific recognition of the unwanted mitochondria and phagophore, which is mediated by the interaction between the degradation signal on the unwanted mitochondria and the receptor on the phagophore. Quite a few mitophagy recognition pathways were found recently, however, it is still not clear that these mitophagy signals are started and regulated. This review summarizes the latest advances in the study of mitophagy to provide references for studying mitophagy and related fields.