布地奈德联合特布他林治疗婴幼儿毛细支气管炎对肺功能及再次喘息的影响

Budesonide Combined with Terbutaline on Pulmonary Function and Recurrent Wheezing in Infants with Bronchiolitis

目的:探讨布地奈德联合特布他林治疗对婴幼儿毛细支气管炎患儿肺功能和再次喘息的影响。方法:选取2014年3月至2015年10月我院儿科病区住院治疗的126例毛细支气管患儿,采用随机数表法分为对照组和观察组各63例。两组患儿入院后均接受常规治疗,对照组在常规治疗基础上应用布地奈德混悬液氧气驱动雾化吸入治疗,观察组在常规治疗基础上应用布地奈德联合特布他林氧气驱动雾化吸入治疗。比较两组患儿治疗前和治疗3 d后的肺功能指标;治疗7 d后评价两组患儿的治疗效果、临床症状消失时间;随访记录两组患儿1年内发生再次喘息的情况。结果:治疗3 d后,观察组患儿肺功能指标改善情况优于对照组(P<0.05);治疗7 d后,观察组总有效率93.65%,高于对照组的74.60%(P<0.01),喘憋消失时间、咳嗽消失时间、哮鸣音消失时间、心率恢复正常时间、住院时间均短于对照组(P<0.01);随访1年,观察组再次喘息发生率17.46%,低于对照组的49.21%(P<0.01)。结论:布地奈德联合特布他林治疗婴幼儿毛细支气管炎,效果显著,可快速缓解症状,改善肺功能,降低喘息复发风险,值得临床推广应用。

Objective： To investigate the effects of budesonide combined with terbutaline on pulmonary function and recurrent wheezing in infants with bronchiolitis. Methods： One hundred and twenty-six children with bronchiolitis admitted into the pediatric ward of our hospital from March 2014 to Oct. 2015 were extracted to be divided into control group and observation group according to the random number table, with 63 cases in each. Children in two groups were treated with conventional treatment after admission ; the control group was treated with budesonide suspension atomizing inhalation treatment based on the conventional treatment, while the observation group additionally received terbutaline combined with budesonide suspension liquid oxygen atomizing inhalation therapy. The pulmonary function of two groups was compared before treatment and after treatment of 3 d. The treatment effects, disappearance time of clinical symptoms of two groups were evaluated after treatment of 7 d. Two groups of children were followed up to record the number of children with recurrent wheezing for a period of one year. Results ： After treatment of 3 d, the improvement of pulmonary function indicators in observation group was better than that in control group （ P〈0. 05 ）. After treatment of 7 d, the total efficiency rate of observation group was 93.65% , higher than that of control group 74.60% （ P〈0.01 ） , and the disappearance time of dyspnea, cough, wheezing, recovery time of heart rate and length of stay in observation group were shorter than those of control group （P〈0. 01 ）. After 1 year of follow-up, the recurrence rate of observation group was 17.46% , lower than that of control group 49.21% （P〈0.01）. Conclusion： The effects of budesonide combined with terbutaline in the treatment of infant bronchiolitis is significant, which can timely help children to relieve the symptoms, improve lung function and reduce the risk of recurrent wheezing, it is worthy of clinical application.