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小剂量HAG方案联合地西他滨治疗老年急性髓系白血病的临床效果观察 被引量:1

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摘要 目的观察小剂量HAG方案联合地西他滨治疗老年急性髓系白血病的临床效果。方法选取我院2016年3月至2017年7月治疗的老年急性髓系白血病患者60例为研究对象,按照随机数表法将其分为两组,各30例。观察组给予小剂量HAG(阿糖胞苷+高三尖杉酯碱+重组人粒细胞集落刺激因子)联合地西他滨治疗方案进行化疗,对照组给予CAG(阿克拉霉素+阿糖胞苷+粒细胞集落刺激因子)治疗方案进行化疗。比较两组治疗效果、外周血T淋巴细胞亚群指标及不良反应。结果与对照组相比,观察组治疗总有效率高,差异有统计学意义(P<0.05);对照组CD8^+比观察组高,CD4^+及CD4^+/CD8^+比观察组低,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论小剂量HAG方案联合地西他滨可有效调节老年急性髓系白血病患者T淋巴细胞亚群相关指标,治疗效果显著,且用药具有一定的安全性。
作者 王萍 张佳佳
出处 《海峡药学》 2018年第5期157-159,共3页 Strait Pharmaceutical Journal
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