沙美特罗替卡松对哮喘患儿嗜酸粒细胞和免疫球蛋白E及肺功能转归的影响

Influence of Salmeterol and Fluticasone Propionate on eosinophil and immunoglobulin E and pulmonary function outcome in children patients with asthma

目的探讨沙美特罗替卡松对哮喘患儿外周血嗜酸粒细胞(EOS)和免疫球蛋白E(IgE)及肺功能转归的影响。方法选取我院2015年3月~2017年9月收治的62例哮喘患儿作为研究对象,按照随机数字表法分为对照组(31例)与观察组(31例)。对照组采用丙酸氟替卡松雾化吸入法,观察组采用沙美特罗替卡松雾化吸入法。记录两组的临床疗效,并比较两组治疗前及治疗4周后的外周血EOS、IgE水平、肺功能[用力肺活量(FVC)、1 s用力呼气容积(FEV1)、呼气峰流速(PEF)]差异。结果观察组的疗效明显优于对照组,差异有统计学意义(P<0.05)。治疗4周后,观察组的外周血EOS、IgE水平均低于对照组,差异有统计学意义(P<0.05);FVC、PEF、FEV1则高于对照组,差异有统计学意义(P<0.05)。两组治疗后的外周血EOS、IgE水平均低于治疗前,差异有统计学意义(P<0.05);FVC、PEF、FEV1则高于对照组,差异有统计学意义(P<0.05)。结论沙美特罗替卡松可减轻哮喘患儿机体炎性反应,改善其免疫功能,还能提高患儿肺功能,于患儿病情转归有利。

Objective To explore the influence of Salmeterol and Fluticasone Propionate（Seretide） on peripheral blood eosinophils（EOS）,immunoglobulin E（IgE） and pulmonary function outcome in asthmatic children patients.Methods A total of 62 children patients with asthma in our hospital from March 2015 to September 2017 were selected for the study and were divided into the control group（n=31） and the observation group（n=31）.The control group was given Fluticasone Propionate aerosol inhalation,and the observation group was given Salmeterol and Fluticason aerosol inhalation.The clinical efficacy was recorded in the two groups,and the levels of peripheral blood EOS and IgE,and pulmonary function（forced vital capacity [FVC],forced expiratory volume in 1 second [FEV1],peak expiratory flow rate [PEF]）were compared between the two groups before treatment and after 4 weeks of treatment.Results The efficacy in the observation group was better than that in the control group,with significant difference（P〈0.05）.After 4 weeks of treatment,the levels of peripheral blood EOS and IgE in the observation group were lower than those in the control group,with significant difference（P〈0.05）,while the levels of FVC,PEF and EFV1 were higher than those in the control group,with significant difference（P〈0.05）.After treatment,the levels of EOS and IgE in peripheral blood were lower than those before treatment（P〈0.05）,while the levels of FVC,PEF and FEV1 were higher than those before treatment（P〈0.05）.Conclusion Salmeterol and Fluticasone Propionate can not only reduce the inflammatory response of asthmatic children patients and improve the immune function,but also enhance pulmonary function,and it is favorable for disease outcome.