靶向抑制Sonic Hedgehog信号通路在白血病中的研究进展

Progress of targeting inhibition of Sonic Hedgehog signaling pathway in leukemia

Sonic Hedgehog（SHH）信号通路在胚胎发育过程中参与调控多个器官以及组织的生长发育，并维持其正常的结构和功能，但在成年人组织中处于抑制状态。异常激活的SHH信号通路在多种恶性肿瘤的发生、发展以及耐药过程中起着重要作用。SHH信号通路在白血病中表现出和实体肿瘤相似的作用机制。随着对SHH信号通路研究的深入，出现了许多该信号通路的靶向抗肿瘤药物，针对该通路研制新的靶向抑制剂将成为治疗白血病的一种新方法。文章就SHH信号通路的靶向抑制剂在白血病中的研究进展作一综述。

Sonic Hedgehog （SHH） signaling pathway participates in the regulation of various organs and growth of tissue cells, maintains normal function and structure in the development of embryogenesis, however, SHH signaling pathway is in a state of inhibition. Meanwhile, the abnormal regulation of SHH signaling pathway plays an important role in the occurrence, development and drug resistance of leukemia. The mechanism of SHH signaling pathway in leukemia is similar to the solid tumor. With the further understanding of SHH signaling pathway, there are many antitumor drugs targeting SHH signaling pathway. The targeting inhibitors targeted SHH signaling pathway will become a new method for the treatment of leukemia. This paper reviews the application of the inhibitors targeting SHH signaling pathway in leukemia.